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Tbio
OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

Protein Summary
Description
The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374103
  • ENSP00000363216
  • ENSG00000197444
  • ENST00000419399
  • ENSP00000401356
  • ENST00000432695
  • ENSP00000390240

Symbol
  • KIAA1290
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.76
molecular function
0.7
cellular component
0.62
pathway
0.59
gene perturbation
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
p_int:  1
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS36
Tdark
Novelty:  0.23031933
p_int:  0.999998698
p_ni:  0.00000128
p_wrong:  2.2e-8
Score:  0.554
Data Source:  BioPlex,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.99998144
p_ni:  0.000018521
p_wrong:  3.9e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
ACBD7
Tdark
Novelty:  0.32019061
p_int:  0.999946044
p_ni:  0.000053718
p_wrong:  2.38e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
DLST
Tbio
Family:  Enzyme
Novelty:  0.01516932
Score:  0.998
Data Source:  STRINGDB
IDH3A
Tbio
Family:  Enzyme
Novelty:  0.02027198
Score:  0.974
Data Source:  STRINGDB
IDH3B
Tbio
Family:  Enzyme
Novelty:  0.04326765
Score:  0.967
Data Source:  STRINGDB
IDH3G
Tbio
Family:  Enzyme
Novelty:  0.04861242
Score:  0.963
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.94
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.939
Data Source:  STRINGDB
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Citrate cycle (TCA cycle)
KEGG
Carbon metabolism
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Citrate cycle (TCA cycle)
Carbon metabolism
Metabolic pathways
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
66.3
glomerular filtration rate
2
2
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
66.3
glomerular filtration rate
2
65.3
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxoglutarate dehydrogenase like
450453
Macaque
oxoglutarate dehydrogenase like
709776
Mouse
MGI:3616088
239017
Rat
RGD:1310916
290566
Dog
oxoglutarate dehydrogenase like
VGNC:44104
477748
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxoglutarate dehydrogenase like
Macaque
oxoglutarate dehydrogenase like
Mouse
Rat
Dog
oxoglutarate dehydrogenase like
Publication Statistics
PubMed Score 20.02
PubMed score by year
PubTator Score 4.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title