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Tbio
ODF2
Outer dense fiber protein 2

Protein Summary
Description
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351030
  • ENSP00000342581
  • ENSG00000136811
  • ENST00000372791
  • ENSP00000361877
  • ENST00000372807
  • ENSP00000361893
  • ENST00000372814
  • ENSP00000361901
  • ENST00000393527
  • ENSP00000377161
  • ENST00000393533
  • ENSP00000377166
  • ENST00000434106
  • ENSP00000403453
  • ENST00000444119
  • ENSP00000394506
  • ENST00000448249
  • ENSP00000396687
  • ENST00000546203
  • ENSP00000437579
  • ENST00000604420
  • ENSP00000473949

Symbol
  • CT134
  • ODF84
  • ODF2/1
  • ODF2/2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor
0.82
small molecule perturbation
0.8
kinase perturbation
0.71
histone modification site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.38   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.38   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0