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Tbio
ODF1
Outer dense fiber protein 1

Protein Summary
Description
Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285402
  • ENSP00000285402
  • ENSG00000155087

Symbol
  • HSPB10
  • ODFP
  • ODF
  • RT7
  • ODF2
  • ODFP
  • SODF
  • CT133
  • ODF27
  • ODFPG
  • HSPB10
  • ODFPGA
  • ODFPGB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.82
tissue sample
0.67
kinase perturbation
0.6
gene perturbation
0.53
cell type or tissue
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.3   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.3   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
SPATA20
Tdark
Novelty:  0.34126403
p_int:  0.999925578
p_ni:  0.000074422
Score:  0.368
Data Source:  BioPlex,STRINGDB
NIF3L1
Tbio
Novelty:  0.15581813
p_int:  0.999587881
p_ni:  0.000412119
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.974714576
p_ni:  0.025285424
Score:  0.576
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.925736054
p_ni:  0.074263946
Score:  0.219
Data Source:  BioPlex,STRINGDB
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.911397027
p_ni:  0.088602973
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.90404594
p_ni:  0.09595406
Score:  0.602
Data Source:  BioPlex,STRINGDB
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
p_int:  0.897951195
p_ni:  0.102048805
Score:  0.188
Data Source:  BioPlex,STRINGDB
PDCL
Tbio
Novelty:  0.00317454
p_int:  0.893535801
p_ni:  0.10646419
p_wrong:  9e-9
Score:  0.529
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.863278849
p_ni:  0.136721151
Score:  0.185
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.832532122
p_ni:  0.167467878
Score:  0.229
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
1
1
8.4
68.6
urate measurement
2
2
2
60.9
C-reactive protein measurement
2
2
2
39.5
serum IgM measurement
1
1
1
32.9
mean platelet volume
2
1
2
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
8.4
68.6
urate measurement
2
60.9
C-reactive protein measurement
2
39.5
serum IgM measurement
1
32.9
mean platelet volume
2
21.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
outer dense fiber of sperm tails 1
VGNC:829
464323
Macaque
outer dense fiber of sperm tails 1
707269
Mouse
MGI:97424
18285
Rat
RGD:3228
24610
Dog
outer dense fiber of sperm tails 1
VGNC:44098
475057
Species
Name
OMA
EggNOG
Inparanoid
Chimp
outer dense fiber of sperm tails 1
Macaque
outer dense fiber of sperm tails 1
Mouse
Rat
Dog
outer dense fiber of sperm tails 1
Publication Statistics
PubMed Score 72.30
PubMed score by year
PubTator Score 90.75
PubTator score by year
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Related Publications
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PMID
Year
Title