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Tbio
ODAPH
Odontogenesis associated phosphoprotein

Protein Summary
Description
May promote nucleation of hydroxyapatite. Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311623
  • ENSP00000311307
  • ENSG00000174792
  • ENST00000435974
  • ENSP00000406925

Symbol
  • C4orf26
  • AI2A4
  • C4orf26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
NUDT8
Tdark
Novelty:  0.76306116
p_int:  0.999998484
p_ni:  0.000001515
p_wrong:  1e-9
Score:  0.311
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.999948462
p_ni:  0.000051538
Data Source:  BioPlex
ANKRD50
Tdark
Novelty:  0.7929169
p_int:  0.999762236
p_ni:  0.000004671
p_wrong:  0.000233093
Score:  0.175
Data Source:  BioPlex,STRINGDB
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999745371
p_ni:  0.000254621
p_wrong:  8e-9
Data Source:  BioPlex
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.999654385
p_ni:  0.000345615
Data Source:  BioPlex
FBN1
Tbio
Novelty:  0.00074957
p_int:  0.999617853
p_ni:  0.000063935
p_wrong:  0.000318212
Score:  0.188
Data Source:  BioPlex,STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.999604617
p_ni:  0.000395285
p_wrong:  9.8e-8
Data Source:  BioPlex
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.999015508
p_ni:  0.000984459
p_wrong:  3.2e-8
Data Source:  BioPlex
NPHP3
Tbio
Novelty:  0.02857926
p_int:  0.998804735
p_ni:  0.001195265
Data Source:  BioPlex
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.998774298
p_ni:  0.00118123
p_wrong:  0.000044472
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
79.2
1
1
0
1.2
49.5
2
2
2
49.4
high density lipoprotein cholesterol measurement
1
1
1
21.5
self reported educational attainment
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
79.2
0
1.2
49.5
2
49.4
high density lipoprotein cholesterol measurement
1
21.5
self reported educational attainment
1
2.3
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
odontogenesis associated phosphoprotein
VGNC:2942
739660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
odontogenesis associated phosphoprotein
Publication Statistics
PubMed Score 4.42
PubMed score by year
PubTator Score 3.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title