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Tbio
OCIAD1
OCIA domain-containing protein 1

Protein Summary
Description
Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264312
  • ENSP00000264312
  • ENSG00000109180
  • ENST00000381473
  • ENSP00000370882
  • ENST00000396448
  • ENSP00000379725
  • ENST00000425583
  • ENSP00000416943
  • ENST00000444354
  • ENSP00000399656
  • ENST00000508293
  • ENSP00000423002
  • ENST00000513391
  • ENSP00000423909

Symbol
  • ASRIJ
  • OCIA
  • OCIA
  • ASRIJ
  • TPA018
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.95
disease perturbation
0.83
ligand (protein) perturbation
0.83
histone modification site profile
0.82
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0