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Tbio
OBSL1
Obscurin-like protein 1

Protein Summary
Description
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. Cytoskeletal adaptor proteins function in linking the internal cytoskeleton of cells to the cell membrane. This gene encodes a cytoskeletal adaptor protein, which is a member of the Unc-89/obscurin family. The protein contains multiple N- and C-terminal immunoglobulin (Ig)-like domains and a central fibronectin type 3 domain. Mutations in this gene cause 3M syndrome type 2. Alternatively spliced transcript variants encoding different isoforms have been found in this gene. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373873
  • ENSP00000362980
  • ENSG00000124006
  • ENST00000404537
  • ENSP00000385636
  • ENST00000603926
  • ENSP00000474519

Symbol
  • KIAA0657
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
protein domain
0.85
PubMedID
0.77
cellular component
0.72
interacting protein
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
MISP
Tbio
Novelty:  0.02030151
p_int:  0.99995286
p_ni:  0.00004714
Data Source:  BioPlex
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999748395
p_ni:  0.000251605
Score:  0.758
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999490129
p_ni:  0.000509871
Data Source:  BioPlex
PAK5
Tchem
Family:  Kinase
Novelty:  0.02138632
p_int:  0.999123518
p_ni:  0.000876482
Data Source:  BioPlex
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.997569817
p_ni:  0.002430183
Data Source:  BioPlex
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.995276715
p_ni:  0.004723285
Data Source:  BioPlex
ADPRH
Tbio
Family:  Enzyme
Novelty:  0.1210664
p_int:  0.992561611
p_ni:  0.007438389
Score:  0.209
Data Source:  BioPlex,STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
p_int:  0.984538502
p_ni:  0.015461498
Data Source:  BioPlex
ANTXR1
Tbio
Novelty:  0.00508081
p_int:  0.97826208
p_ni:  0.02173792
Score:  0.204
Data Source:  BioPlex,STRINGDB
PHF8
Tchem
Family:  Epigenetic
Novelty:  0.01946151
p_int:  0.974697554
p_ni:  0.025302446
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
3
85.1
creatinine measurement
1
1
1
73.7
electrocardiography
1
1
60
68.6
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
53.3
vital capacity
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
85.1
creatinine measurement
1
73.7
electrocardiography
60
68.6
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
53.3
vital capacity
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
obscurin like 1
VGNC:14328
459967
Mouse
MGI:2138628
98733
Rat
RGD:1306073
363259
Cow
obscurin like 1
VGNC:32395
511087
Pig
obscurin like 1
100624019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
obscurin like 1
Mouse
Rat
Cow
obscurin like 1
Pig
obscurin like 1
Publication Statistics
PubMed Score 29.46
PubMed score by year
PubTator Score 14.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title