You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OBP2A
Odorant-binding protein 2a

Protein Summary
Description
Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids. This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371776
  • ENSP00000360841
  • ENSG00000122136
  • ENST00000539850
  • ENSP00000441028

Symbol
  • OBP
  • LCN13
  • OBP2C
  • OBPIIa
  • hOBPIIa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
protein domain
0.58
cell line
0.55
phenotype
0.48
disease
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
OBP2B
Tdark
Novelty:  0.43500456
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.776
Data Source:  BioPlex,STRINGDB
ERBIN
Tbio
Novelty:  0.01419561
p_int:  0.927779222
p_ni:  0.072220778
Score:  0.189
Data Source:  BioPlex,STRINGDB
TXNDC15
Tbio
Novelty:  0.23488442
p_int:  0.911706583
p_ni:  0.088237801
p_wrong:  0.000055617
Score:  0.177
Data Source:  BioPlex,STRINGDB
COL6A2
Tbio
Novelty:  0.01275082
p_int:  0.872619755
p_ni:  0.127380245
Score:  0.177
Data Source:  BioPlex,STRINGDB
CLN5
Tbio
Novelty:  0.01124343
p_int:  0.76740374
p_ni:  0.23259626
Score:  0.345
Data Source:  BioPlex,STRINGDB
KIF22
Tbio
Novelty:  0.0109594
Score:  0.815
Data Source:  STRINGDB
APOD
Tbio
Novelty:  0.0031899
Score:  0.719
Data Source:  STRINGDB
LCN15
Tdark
Novelty:  0.54935158
Score:  0.657
Data Source:  STRINGDB
LCN10
Tdark
Novelty:  1.32107702
Score:  0.65
Data Source:  STRINGDB
LCN9
Tdark
Novelty:  0.25490072
Score:  0.63
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
3
3
89.6
1
1
0
1.6
55.7
chemotherapy-induced cytotoxicity measurement
1
1
1
45.4
metabolite measurement
1
1
1
21.2
lymphocyte count
3
1
3
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
89.6
0
1.6
55.7
chemotherapy-induced cytotoxicity measurement
1
45.4
metabolite measurement
1
21.2
lymphocyte count
3
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 49.68
PubMed score by year
PubTator Score 110.65
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title