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Tbio
OAZ3
Ornithine decarboxylase antizyme 3

Protein Summary
Description
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high level ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000627780
  • ENSP00000486158
  • ENSG00000143450
  • ENST00000639906
  • ENSP00000492131

Symbol
  • AZ3
  • OAZ-t
  • TISP15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
tissue sample
0.7
histone modification site profile
0.68
biological process
0.64
transcription factor
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.2   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.2   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
AZIN1
Tbio
Family:  Enzyme
Novelty:  0.03017595
p_int:  1
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
FABP4
Tchem
Novelty:  0.00107707
p_int:  0.999998713
p_ni:  0.000001242
p_wrong:  4.5e-8
Score:  0.242
Data Source:  BioPlex,STRINGDB
TCHH
Tbio
Novelty:  0.00303837
p_int:  0.999988637
p_ni:  0.000002483
p_wrong:  0.000008881
Score:  0.189
Data Source:  BioPlex,STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
p_int:  0.999963741
p_ni:  0.000036259
Score:  0.161
Data Source:  BioPlex,STRINGDB
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.999606701
p_ni:  0.000393299
Data Source:  BioPlex
PADI3
Tchem
Family:  Enzyme
Novelty:  0.01110139
p_int:  0.999112229
p_ni:  0.000887758
p_wrong:  1.3e-8
Data Source:  BioPlex
IL1F10
Tbio
Novelty:  0.01868526
p_int:  0.999103925
p_ni:  0.000001264
p_wrong:  0.000894812
Score:  0.303
Data Source:  BioPlex,STRINGDB
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.998991175
p_ni:  0.00100811
p_wrong:  7.15e-7
Data Source:  BioPlex
PKP3
Tbio
Novelty:  0.0269462
p_int:  0.996862734
p_ni:  0.003137261
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
1
2
81.7
2
3
0
1.1
77.1
vitamin D measurement
1
2
2
73.6
Eczema
1
1
0
1.1
73.5
1
1
0
1.1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
81.7
0
1.1
77.1
vitamin D measurement
2
73.6
Eczema
0
1.1
73.5
0
1.1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ornithine decarboxylase antizyme 3
VGNC:1424
469486
Macaque
ornithine decarboxylase antizyme 3
711313
Mouse
MGI:1858170
53814
Rat
RGD:1599278
689588
Dog
ornithine decarboxylase antizyme 3
VGNC:44091
475850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ornithine decarboxylase antizyme 3
Macaque
ornithine decarboxylase antizyme 3
Mouse
Rat
Dog
ornithine decarboxylase antizyme 3
Publication Statistics
PubMed Score 42.20
PubMed score by year
PubTator Score 9.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title