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Tbio
OAS1
2'-5'-oligoadenylate synthase 1

Protein Summary
Description
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. This gene is ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
1
PubMedID
0.98
molecular function
0.96
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.67   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.67   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
ISG15
Tbio
Novelty:  0.00203781
Score:  0.997
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.997
Data Source:  STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
Score:  0.995
Data Source:  STRINGDB
IFI6
Tbio
Novelty:  0.02590679
Score:  0.994
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.993
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.992
Data Source:  STRINGDB
IFI35
Tbio
Novelty:  0.04309126
Score:  0.99
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.989
Data Source:  STRINGDB
MX2
Tbio
Novelty:  0.00139073
Score:  0.989
Data Source:  STRINGDB
IFIT2
Tbio
Novelty:  0.01023074
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
83.2
alcohol drinking
1
1
0
1.6
66.3
alcohol consumption measurement
1
1
0
1.6
66.3
high density lipoprotein cholesterol measurement
1
1
0
1.4
52.4
COVID-19
1
1
0
1.2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
83.2
alcohol drinking
0
1.6
66.3
alcohol consumption measurement
0
1.6
66.3
high density lipoprotein cholesterol measurement
0
1.4
52.4
COVID-19
0
1.2
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2'-5'-oligoadenylate synthetase 1
VGNC:5516
739129
Macaque
2'-5'-oligoadenylate synthetase 1
712265
Mouse
MGI:97429
23960
Rat
RGD:6497100
100910735
Dog
2'-5'-oligoadenylate synthetase 1
VGNC:44086
608778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2'-5'-oligoadenylate synthetase 1
Macaque
2'-5'-oligoadenylate synthetase 1
Mouse
Rat
Dog
2'-5'-oligoadenylate synthetase 1
Publication Statistics
PubMed Score 182.67
PubMed score by year
PubTator Score 99.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title