Tbio B3GALT4 Beta-1,3-galactosyltransferase 4

Protein Summary

Description

Involved in GM1/GD1B/GA1 ganglioside biosynthesis. This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O96024
• Beta-1,3-GalTase 4

Gene Name

• B3GALT4

Ensembl ID

• ENST00000383209
• ENSP00000372696
• ENSG00000206285
• ENST00000415322
• ENSP00000394876
• ENSG00000226936
• ENST00000419471
• ENSP00000398660
• ENSG00000235155
• ENST00000430971
• ENSP00000414880
• ENSG00000236802
• ENST00000451237
• ENSP00000390784
• ENSG00000235863

Symbol

• GALT4
• GALT2
• GALT4
• BETA3GALT4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.82
virus perturbation	0.79
tissue sample	0.67
disease perturbation	0.62
small molecule perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,3-galactosyltransferase 4

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,3-galactosyltransferase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.04   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.04   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0