Tbio CCNE2 G1/S-specific cyclin-E2

Protein Summary

Description

Essential for the control of the cell cycle at the late G1 and early S phase. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O96020
• O95439

Gene Name

• CCNE2

Ensembl ID

• ENST00000308108
• ENSP00000309181
• ENSG00000175305
• ENST00000520509
• ENSP00000429089

Symbol

• CYCE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.94
histone modification site profile	0.87
gene perturbation	0.85
small molecule perturbation	0.84
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-e2

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-e2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.43   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.43   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0