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Tbio
CCNE2
G1/S-specific cyclin-E2

Protein Summary
Description
Essential for the control of the cell cycle at the late G1 and early S phase. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308108
  • ENSP00000309181
  • ENSG00000175305
  • ENST00000520509
  • ENSP00000429089

Symbol
  • CYCE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
histone modification site profile
0.87
gene perturbation
0.85
small molecule perturbation
0.84
transcription factor binding site profile
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.2   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.2   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin E2
VGNC:905
464292
Macaque
cyclin E2
700382
Mouse
MGI:1329034
12448
Rat
RGD:1307783
362485
Dog
cyclin E2
VGNC:54109
487057
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin E2
Macaque
cyclin E2
Mouse
Rat
Dog
cyclin E2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O96020-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (62)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
CDK-mediated phosphorylation and removal of Cdc6
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Protein-Protein Interactions (269)
1 – 10 of 269
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999993563
p_ni: 0.000006427
p_wrong: 1e-8
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
L3HYPDH
Tdark
Family: Enzyme
Novelty: 0.35456591
p_int: 0.999971214
p_ni: 0.000018502
p_wrong: 0.000010284
Score: 0.193
Data Source: BioPlex,STRINGDB
CDK3
Tchem
Family: Kinase
Novelty: 0.03380289
p_int: 0.999961341
p_ni: 0.000038652
p_wrong: 7e-9
Score: 0.945
Data Source: BioPlex,STRINGDB
CKS1B
Tbio
Family: Enzyme
Novelty: 0.00766779
p_int: 0.99993577
p_ni: 0.00003981
p_wrong: 0.00002442
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
p_int: 0.889944577
p_ni: 0.000123419
p_wrong: 0.109932004
Score: 0.931
Data Source: BioPlex,STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
Score: 0.995
Data Source: Reactome,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.992
Data Source: STRINGDB
CDC6
Tbio
Novelty: 0.00219371
Score: 0.989
Data Source: Reactome,STRINGDB
CDC25A
Tchem
Family: Enzyme
Novelty: 0.00250149
Score: 0.981
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  108.20

PubMed score by year
PubTator Score  67.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer