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Tchem
CHEK2
Serine/threonine-protein kinase Chk2

Protein Summary
Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphory ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328354
  • ENSP00000329178
  • ENSG00000183765
  • ENST00000348295
  • ENSP00000329012
  • ENST00000382580
  • ENSP00000372023
  • ENST00000402731
  • ENSP00000384835
  • ENST00000403642
  • ENSP00000384919
  • ENST00000404276
  • ENSP00000385747
  • ENST00000405598
  • ENSP00000386087
  • ENST00000417588
  • ENSP00000412901
  • ENST00000433728
  • ENSP00000404400
  • ENST00000448511
  • ENSP00000404567
  • ENST00000649563
  • ENSP00000496928
  • ENST00000650281
  • ENSP00000497000

Symbol
  • CDS1
  • CHK2
  • RAD53
  • CDS1
  • CHK2
  • LFS2
  • RAD53
  • hCds1
  • HuCds1
  • PP1425
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase
0.99
molecular function
0.99
biological process
0.96
hub protein
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1487.6   (req: < 5)
Gene RIFs: 391   (req: <= 3)
Antibodies: 1805   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1487.6   (req: >= 5)
Gene RIFs: 391   (req: > 3)
Antibodies: 1805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 148
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (501)
TP63
Tbio
Family:  TF
Novelty:  0.00336108
p_int:  0.999999933
p_ni:  5.3e-8
p_wrong:  1.4e-8
Score:  0.71
Data Source:  BioPlex,STRINGDB
TEX264
Tbio
Novelty:  0.32406417
p_int:  0.999520319
p_ni:  0.000040482
p_wrong:  0.000439199
Score:  0.224
Data Source:  BioPlex,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.999
Data Source:  Reactome,STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
Score:  0.999
Data Source:  STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
Score:  0.998
Data Source:  Reactome,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.998
Data Source:  Reactome,STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.998
Data Source:  Reactome,STRINGDB
CDC25A
Tchem
Family:  Enzyme
Novelty:  0.00250149
Score:  0.997
Data Source:  Reactome,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.993
Data Source:  STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.992
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
CDK6
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  3
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  1
Pathways (45)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
DNA Double Strand Break Response
DNA Double-Strand Break Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
4
5
6
97.7
red blood cell distribution width
4
4
5
95.5
sex hormone-binding globulin measurement
6
2
6
92.1
optic disc size measurement
3
2
3
90.6
2
3
0
1.5
89.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
6
97.7
red blood cell distribution width
5
95.5
sex hormone-binding globulin measurement
6
92.1
optic disc size measurement
3
90.6
0
1.5
89.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
checkpoint kinase 2
VGNC:12828
458733
Macaque
checkpoint kinase 2
713668
Mouse
MGI:1355321
50883
Rat
RGD:621543
114212
Dog
checkpoint kinase 2
VGNC:39209
486338
Species
Name
OMA
EggNOG
Inparanoid
Chimp
checkpoint kinase 2
Macaque
checkpoint kinase 2
Mouse
Rat
Dog
checkpoint kinase 2
Publication Statistics
PubMed Score 1487.60
PubMed score by year
PubTator Score 1011.59
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title