Tbio WNT11 Protein Wnt-11

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-11

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O96014
• B2R8Z6
• Q14DE8
• Q8WZ98

Gene Name

• WNT11

Ensembl ID

• ENST00000322563
• ENSP00000325526
• ENSG00000085741

Symbol

• HWNT11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.79
transcription factor binding site profile	0.74
PubMedID	0.69
gene perturbation	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.14   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.14   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (119)

Reactome (9)

KEGG (13)

PathwayCommons (29)

WikiPathways (68)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
PCP/CE pathway	93 targets	R-HSA-4086400

Gene Ontology Terms (58)

Functions (4)

Components (4)

Processes (50)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
GTPase activator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
protein kinase activator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (198)

Explore Interacting Targets

1 – 10 of 198

• See Interactions on String-DB

KLRG2

Tdark

Novelty: 0.77419355

p_int: 0.999981231

p_ni: 0.000002386

p_wrong: 0.000016384

Score: 0.173

Data Source: BioPlex,STRINGDB

PLA2G10

Tchem

Family: Enzyme

Novelty: 0.00367717

p_int: 0.999913042

p_ni: 0.000083127

p_wrong: 0.000003832

Score: 0.177

Data Source: BioPlex,STRINGDB

TMED7

Tdark

Novelty: 0.57942602

p_int: 0.999621162

p_ni: 0.000246087

p_wrong: 0.000132751

Data Source: BioPlex

RETNLB

Tbio

Novelty: 0.00979708

p_int: 0.798342296

p_ni: 0.000178091

p_wrong: 0.201479613

Data Source: BioPlex

WNT16

Tbio

Novelty: 0.01638935

p_int: 0.756860243

p_ni: 0.000460793

p_wrong: 0.242678964

Score: 0.937

Data Source: BioPlex,STRINGDB

FZD7

Tbio

Family: GPCR

Novelty: 0.01307342

Score: 0.986

Data Source: Reactome,STRINGDB

DVL2

Tbio

Novelty: 0.01142063

Score: 0.978

Data Source: Reactome,STRINGDB

FZD1

Tbio

Family: GPCR

Novelty: 0.00772255

Score: 0.978

Data Source: Reactome,STRINGDB

DVL1

Tchem

Novelty: 0.00460899

Score: 0.978

Data Source: STRINGDB

FZD2

Tbio

Family: GPCR

Novelty: 0.01294873

Score: 0.977

Data Source: STRINGDB

Publication Statistics

PubMed Score  147.14

PubMed score by year

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PubTator Score  69.16

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVV

1-70

HAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSC

70-140

GPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCK

140-210

CHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSP

210-280

DFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVER

280-350

YVCK

350-354

MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK

Find similar targets by:

Uniprot Keyword

Complete proteome
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal
Wnt signaling pathway