Protein Classes
Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]
- ENST00000322563
- ENSP00000325526
- ENSG00000085741
- HWNT11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.79 | ||
transcription factor binding site profile | 0.74 | ||
PubMedID | 0.69 | ||
gene perturbation | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 200.16 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 200.16 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 54
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
PR interval | 1 | 1 | 0 | 1.2 | 37.2 | ||||
platelet crit | 1 | 1 | 1 | 21 | |||||
platelet count | 1 | 1 | 1 | 8.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
PR interval | 0 | 1.2 | 37.2 | ||||
platelet crit | 1 | 21 | |||||
platelet count | 1 | 8.5 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 11 | VGNC:7744 | 451431 | |||||
Macaque | Wnt family member 11 | 696845 | ||||||
Mouse | MGI:101948 | 22411 | ||||||
Rat | RGD:621463 | 140584 | ||||||
Dog | Wnt family member 11 | VGNC:48421 | 485183 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Wnt family member 11 | |||||
Macaque | Wnt family member 11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 11 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (119)
Reactome (9)
KEGG (13)
PathwayCommons (29)
WikiPathways (68)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | PCP/CE pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
PCP/CE pathway | ||||
Gene Ontology Terms (58)
Functions (4)
Components (4)
Processes (50)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (198)
1 – 10 of 198
KLRG2
Novelty: 1.19446694
p_int: 0.999981231
p_ni: 0.000002386
p_wrong: 0.000016384
Score: 0.173
Data Source: BioPlex,STRINGDB
PLA2G10
Family: Enzyme
Novelty: 0.00289317
p_int: 0.999913042
p_ni: 0.000083127
p_wrong: 0.000003832
Score: 0.177
Data Source: BioPlex,STRINGDB
TMED7
Novelty: 0.31193294
p_int: 0.999621162
p_ni: 0.000246087
p_wrong: 0.000132751
Data Source: BioPlex
RETNLB
Novelty: 0.00777842
p_int: 0.798342296
p_ni: 0.000178091
p_wrong: 0.201479613
Data Source: BioPlex
WNT16
Novelty: 0.00966869
p_int: 0.756860243
p_ni: 0.000460793
p_wrong: 0.242678964
Score: 0.937
Data Source: BioPlex,STRINGDB
FZD7
Family: GPCR
Novelty: 0.00916448
Score: 0.986
Data Source: Reactome,STRINGDB
DVL2
Novelty: 0.00833084
Score: 0.978
Data Source: Reactome,STRINGDB
FZD1
Family: GPCR
Novelty: 0.01097201
Score: 0.978
Data Source: Reactome,STRINGDB
DVL1
Novelty: 0.00356876
Score: 0.978
Data Source: STRINGDB
FZD2
Family: GPCR
Novelty: 0.00774893
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score 200.16
PubMed score by year
PubTator Score 69.16
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword