Tbio WNT11 Protein Wnt-11

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O96014
• B2R8Z6
• Q14DE8
• Q8WZ98

Gene Name

• WNT11

Ensembl ID

• ENST00000322563
• ENSP00000325526
• ENSG00000085741

Symbol

• HWNT11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.79
transcription factor binding site profile	0.74
PubMedID	0.69
gene perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-11

DTO Classes

Protein / Signaling / Protein Wnt-11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.07   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.07   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (198)

Explore Interacting Targets

1 – 10 of 198

• See Interactions on String-DB

KLRG2

Tdark

Novelty:  1.19446694

p_int:  0.999981231

p_ni:  0.000002386

p_wrong:  0.000016384

Score:  0.173

Data Source:  BioPlex,STRINGDB

PLA2G10

Tchem

Family:  Enzyme

Novelty:  0.00289317

p_int:  0.999913042

p_ni:  0.000083127

p_wrong:  0.000003832

Score:  0.177

Data Source:  BioPlex,STRINGDB

TMED7

Tdark

Novelty:  0.31193294

p_int:  0.999621162

p_ni:  0.000246087

p_wrong:  0.000132751

Data Source:  BioPlex

RETNLB

Tbio

Novelty:  0.00777842

p_int:  0.798342296

p_ni:  0.000178091

p_wrong:  0.201479613

Data Source:  BioPlex

WNT16

Tbio

Novelty:  0.00966869

p_int:  0.756860243

p_ni:  0.000460793

p_wrong:  0.242678964

Score:  0.937

Data Source:  BioPlex,STRINGDB

FZD7

Tchem

Family:  GPCR

Novelty:  0.00916448

Score:  0.986

Data Source:  Reactome,STRINGDB

DVL2

Tbio

Novelty:  0.00833084

Score:  0.978

Data Source:  Reactome,STRINGDB

FZD1

Tchem

Family:  GPCR

Novelty:  0.01097201

Score:  0.978

Data Source:  Reactome,STRINGDB

DVL1

Tchem

Novelty:  0.00356876

Score:  0.978

Data Source:  STRINGDB

FZD2

Tchem

Family:  GPCR

Novelty:  0.00774893

Score:  0.977

Data Source:  STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (2)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  12

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  8 more common pathways

Pathways (119)

Reactome (9)

KEGG (13)

PathwayCommons (29)

WikiPathways (68)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
PCP/CE pathway	93 targets	R-HSA-4086400

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (58)

Functions (4)

Components (4)

Processes (50)

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1 – 4 of 4

GO Term	Evidence	Assigned by
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
GTPase activator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
protein kinase activator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
PR interval	EFO_0004462	1	1	0	1.2	47.4
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		37.7
platelet crit	EFO_0007985	1	1	1		37
platelet count	EFO_0004309	1	1	1		20.5
hemoglobin A1 measurement	EFO_0007629	1	1	1		19.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
PR interval	EFO_0004462	0	1.2	47.4
apolipoprotein A 1 measurement	EFO_0004614	1		37.7
platelet crit	EFO_0007985	1		37
platelet count	EFO_0004309	1		20.5
hemoglobin A1 measurement	EFO_0007629	1		19.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal
Wnt signaling pathway

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
hemoglobin A1 measurement
platelet count
platelet crit
PR interval

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
endocrine/exocrine gland phenotype
mortality/aging
renal/urinary system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 11	VGNC:7744	451431
Macaque	Wnt family member 11		696845
Mouse	wingless-type MMTV integration site family, member 11	MGI:101948	22411
Rat	Wnt family member 11	RGD:621463	140584
Dog	Wnt family member 11	VGNC:48421	485183

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 11
Macaque	Wnt family member 11
Mouse	wingless-type MMTV integration site family, member 11
Rat	Wnt family member 11
Dog	Wnt family member 11

Publication Statistics

PubMed Score 222.07

PubMed score by year

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PubTator Score 69.16

PubTator score by year

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Related Publications

Text Mined References (44)

GeneRif Annotations (33)

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PMID	Year	Title