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Tbio
WNT11
Protein Wnt-11

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322563
  • ENSP00000325526
  • ENSG00000085741

Symbol
  • HWNT11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.79
transcription factor binding site profile
0.74
PubMedID
0.69
gene perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.16   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.16   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
1
1
0
1.2
37.2
platelet crit
1
1
1
21
platelet count
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
1.2
37.2
platelet crit
1
21
platelet count
1
8.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 11
VGNC:7744
451431
Macaque
Wnt family member 11
696845
Mouse
MGI:101948
22411
Rat
RGD:621463
140584
Dog
Wnt family member 11
VGNC:48421
485183
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 11
Macaque
Wnt family member 11
Mouse
Rat
Dog
Wnt family member 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O96014-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (119)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
PCP/CE pathway
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Class B/2 (Secretin family receptors)
GPCR ligand binding
PCP/CE pathway
Protein-Protein Interactions (198)
1 – 10 of 198
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.999981231
p_ni: 0.000002386
p_wrong: 0.000016384
Score: 0.173
Data Source: BioPlex,STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.999913042
p_ni: 0.000083127
p_wrong: 0.000003832
Score: 0.177
Data Source: BioPlex,STRINGDB
TMED7
Tdark
Novelty: 0.31193294
p_int: 0.999621162
p_ni: 0.000246087
p_wrong: 0.000132751
Data Source: BioPlex
RETNLB
Tbio
Novelty: 0.00777842
p_int: 0.798342296
p_ni: 0.000178091
p_wrong: 0.201479613
Data Source: BioPlex
WNT16
Tbio
Novelty: 0.00966869
p_int: 0.756860243
p_ni: 0.000460793
p_wrong: 0.242678964
Score: 0.937
Data Source: BioPlex,STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
Score: 0.986
Data Source: Reactome,STRINGDB
DVL2
Tbio
Novelty: 0.00833084
Score: 0.978
Data Source: Reactome,STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.978
Data Source: Reactome,STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.978
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  200.16

PubMed score by year
PubTator Score  69.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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