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Tchem
PAK4
Serine/threonine-protein kinase PAK 4

Protein Summary
Description
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321944
  • ENSP00000326864
  • ENSG00000130669
  • ENST00000358301
  • ENSP00000351049
  • ENST00000360442
  • ENSP00000353625
  • ENST00000593690
  • ENSP00000469413
  • ENST00000599386
  • ENSP00000471157
  • ENST00000599470
  • ENSP00000470284

Symbol
  • KIAA1142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
0.98
molecular function
0.96
transcription factor
0.77
hub protein
0.75


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.63   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 572   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.63   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 572   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
p21 (RAC1) activated kinase 4
696676
Mouse
MGI:1917834
70584
Rat
RGD:1307705
292756
Dog
p21 (RAC1) activated kinase 4
VGNC:53528
484513
Horse
p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
p21 (RAC1) activated kinase 4
Mouse
Rat
Dog
p21 (RAC1) activated kinase 4
Horse
p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059]
Protein Structure (34 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O96013-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 34
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Developmental Biology
Signaling by ROBO receptors
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (139)
1 – 10 of 139
PAK5
Tchem
Family: Kinase
Novelty: 0.02138632
p_int: 1
Score: 0.955
Data Source: BioPlex,STRINGDB
ARHGEF11
Tbio
Novelty: 0.01942359
p_int: 0.999999597
p_ni: 2.79e-7
p_wrong: 1.25e-7
Score: 0.885
Data Source: BioPlex,STRINGDB
CARMIL1
Tbio
Novelty: 0.04162135
p_int: 0.999998893
p_ni: 0.000001107
Score: 0.815
Data Source: BioPlex,STRINGDB
PAK6
Tchem
Family: Kinase
Novelty: 0.02050802
p_int: 0.999997283
p_ni: 1.7e-8
p_wrong: 0.000002701
Data Source: BioPlex
GGNBP2
Tbio
Novelty: 0.03088714
p_int: 0.999633084
p_ni: 0.000004469
p_wrong: 0.000362447
Score: 0.514
Data Source: BioPlex,STRINGDB
CDK6
Tclin
Family: Kinase
Novelty: 0.00109319
p_int: 0.985539508
p_ni: 0.014460486
p_wrong: 5e-9
Score: 0.426
Data Source: BioPlex,STRINGDB
TMPRSS11A
Tbio
Family: Enzyme
Novelty: 0.06142295
p_int: 0.916365192
p_ni: 0.083634808
Score: 0.221
Data Source: BioPlex,STRINGDB
DDX6
Tbio
Family: Enzyme
Novelty: 0.01032357
p_int: 0.846719185
p_ni: 0.153280815
Score: 0.259
Data Source: BioPlex,STRINGDB
KLHL42
Tdark
Novelty: 0.25822395
p_int: 0.839257567
p_ni: 0.160738531
p_wrong: 0.000003901
Score: 0.204
Data Source: BioPlex,STRINGDB
MTUS2
Tbio
Novelty: 0.13504593
p_int: 0.754088358
p_ni: 0.245911642
Data Source: BioPlex
Publication Statistics
PubMed Score  177.63

PubMed score by year
PubTator Score  98.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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