You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PEX11B
Peroxisomal membrane protein 11B

Protein Summary
Description
Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455). The protein encoded by this gene facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane. Several transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369306
  • ENSP00000358312
  • ENSG00000131779
  • ENST00000537888
  • ENSP00000437510

Symbol
  • PEX14B
  • PEX11-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.98
cellular component
0.82
kinase perturbation
0.71
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999979945
p_ni:  0.000003643
p_wrong:  0.000016412
Score:  0.177
Data Source:  BioPlex,STRINGDB
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.999549322
p_ni:  0.000036626
p_wrong:  0.000414052
Score:  0.177
Data Source:  BioPlex,STRINGDB
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.998650648
p_ni:  0.000919302
p_wrong:  0.00043005
Score:  0.237
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.827826177
p_ni:  0.000034376
p_wrong:  0.172139446
Data Source:  BioPlex
PEX11G
Tbio
Novelty:  0.27261873
Score:  0.975
Data Source:  STRINGDB
PEX3
Tbio
Novelty:  0.01171119
Score:  0.892
Data Source:  STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.878
Data Source:  STRINGDB
PEX11A
Tbio
Novelty:  0.01387985
Score:  0.878
Data Source:  STRINGDB
PEX5
Tbio
Novelty:  0.00560901
Score:  0.876
Data Source:  STRINGDB
PEX19
Tbio
Novelty:  0.00605342
Score:  0.87
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
4
4
91.9
myeloid white cell count
1
1
1
68.8
granulocyte count
1
1
1
46.9
high density lipoprotein cholesterol measurement
1
1
1
40.7
apolipoprotein A 1 measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
91.9
myeloid white cell count
1
68.8
granulocyte count
1
46.9
high density lipoprotein cholesterol measurement
1
40.7
apolipoprotein A 1 measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 11 beta
VGNC:1445
746256
Macaque
peroxisomal biogenesis factor 11 beta
698184
Mouse
MGI:1338882
18632
Rat
RGD:1310353
310682
Dog
peroxisomal biogenesis factor 11 beta
VGNC:44427
475826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 11 beta
Macaque
peroxisomal biogenesis factor 11 beta
Mouse
Rat
Dog
peroxisomal biogenesis factor 11 beta
Publication Statistics
PubMed Score 25.57
PubMed score by year
PubTator Score 10.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title