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Tbio
NAPSA
Napsin-A

Protein Summary
Description
May be involved in processing of pneumocyte surfactant precursors. This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253719
  • ENSP00000253719
  • ENSG00000131400

Symbol
  • NAP1
  • NAPA
  • KAP
  • Kdap
  • NAP1
  • NAPA
  • SNAPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.72
tissue sample
0.63
PubMedID
0.57
gene perturbation
0.55
transcription factor
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.12   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 698   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.12   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 698   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
73
2
1
0
1.4
58.4
platinum measurement
1
1
1
14.2
response to cisplatin
1
1
1
14.2
systolic blood pressure
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
73
0
1.4
58.4
platinum measurement
1
14.2
response to cisplatin
1
14.2
systolic blood pressure
1
11.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
napsin A aspartic peptidase [Source:HGNC Symbol;Acc:HGNC:13395]
Mouse
MGI:109365
16541
Rat
RGD:61940
60575
Dog
napsin A aspartic peptidase
VGNC:43624
476406
Horse
napsin A aspartic peptidase
VGNC:20564
100057514
Species
Name
OMA
EggNOG
Inparanoid
Macaque
napsin A aspartic peptidase [Source:HGNC Symbol;Acc:HGNC:13395]
Mouse
Rat
Dog
napsin A aspartic peptidase
Horse
napsin A aspartic peptidase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O96009-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (49)
1 – 10 of 49
GRN
Tbio
Novelty:  0.00096395
p_int:  0.97861066
p_ni:  0.021389336
p_wrong:  4e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.879198867
p_ni:  0.120801133
Score:  0.408
Data Source:  BioPlex,STRINGDB
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
p_int:  0.802837157
p_ni:  0.197162843
Score:  0.688
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.778460211
p_ni:  0.221539687
p_wrong:  1.03e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
SFTPB
Tbio
Novelty:  0.00163925
Score:  0.957
Data Source:  STRINGDB
SFTPC
Tbio
Novelty:  0.00154396
Score:  0.932
Data Source:  STRINGDB
NKX2-1
Tbio
Family:  TF
Novelty:  0.00077491
Score:  0.84
Data Source:  STRINGDB
KRT7
Tbio
Novelty:  0.00039796
Score:  0.835
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.735
Data Source:  STRINGDB
ALK
Tclin
Family:  Kinase
Novelty:  0.00022375
Score:  0.673
Data Source:  STRINGDB
Publication Statistics
PubMed Score  197.12

PubMed score by year
PubTator Score  345.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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