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Tbio
TOMM40
Mitochondrial import receptor subunit TOM40 homolog

Protein Classes
Protein Summary
Description
Channel-forming protein essential for import of protein precursors into mitochondria. The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252487
  • ENSP00000252487
  • ENSG00000130204
  • ENST00000405636
  • ENSP00000385184
  • ENST00000426677
  • ENSP00000410339
  • ENST00000592434
  • ENSP00000466084

Symbol
  • C19orf1
  • PEREC1
  • TOM40
  • TOM40
  • PEREC1
  • C19orf1
  • PER-EC1
  • D19S1177E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease perturbation
0.93
histone modification site profile
0.89
phenotype
0.89
transcription factor binding site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.63   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.63   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
17
0
2
100
family history of Alzheimer’s disease
2
7
0
8.8
99.6
C-reactive protein measurement
5
3
7
99
low density lipoprotein cholesterol measurement
7
7
11
2.4
99
total cholesterol measurement
5
5
5
2
98.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
100
family history of Alzheimer’s disease
0
8.8
99.6
C-reactive protein measurement
7
99
low density lipoprotein cholesterol measurement
11
2.4
99
total cholesterol measurement
5
2
98.3
Pathways (9)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitochondrial protein import
Reactome
Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitochondrial protein import
Mitophagy
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (240)
1 – 10 of 240
TOMM22
Tbio
Novelty: 0.01217913
p_int: 0.999943778
p_ni: 0.000056222
Score: 0.997
Data Source: BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.969362369
p_ni: 0.030637631
Score: 0.185
Data Source: BioPlex,STRINGDB
WNT4
Tbio
Novelty: 0.00276803
p_int: 0.909849471
p_ni: 0.090150529
Score: 0.189
Data Source: BioPlex,STRINGDB
KRBA1
Tdark
Novelty: 2.59384945
p_int: 0.890735583
p_ni: 0.109264417
Score: 0.173
Data Source: BioPlex,STRINGDB
KLRF1
Tbio
Novelty: 0.05732414
p_int: 0.879009511
p_ni: 0.120990487
p_wrong: 1e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.877480942
p_ni: 0.122519058
Score: 0.945
Data Source: BioPlex,STRINGDB
FOXRED2
Tdark
Family: Enzyme
Novelty: 0.33139597
p_int: 0.871906864
p_ni: 0.128093136
Score: 0.236
Data Source: BioPlex,STRINGDB
CYP2C9
Tchem
Novelty: 0.00041914
p_int: 0.869746857
p_ni: 0.130253143
Score: 0.335
Data Source: BioPlex,STRINGDB
TOMM7
Tbio
Novelty: 0.03885154
p_int: 0.833912544
p_ni: 0.166087455
Score: 0.998
Data Source: BioPlex,STRINGDB
TOMM70
Tbio
Novelty: 0.00943973
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  236.63

PubMed score by year
PubTator Score  150.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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