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Tbio
O96007
Molybdopterin synthase catalytic subunit

Protein Summary
Description
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396954
  • ENSP00000380157
  • ENSG00000164172

Symbol
  • MCBPE
  • MOCO1
  • MPTS
  • MCBPE
  • MOCO1
  • MOCODB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.92
histone modification site profile
0.87
disease perturbation
0.83
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
FANCM
Tbio
Novelty:  0.01122278
p_int:  0.986589255
p_ni:  0.013383627
p_wrong:  0.000027118
Score:  0.685
Data Source:  BioPlex,STRINGDB
MOCS1
Tclin
Novelty:  0.02785369
Score:  0.997
Data Source:  STRINGDB
GPHN
Tbio
Novelty:  0.0020752
Score:  0.993
Data Source:  STRINGDB
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
Score:  0.992
Data Source:  STRINGDB
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
Score:  0.921
Data Source:  STRINGDB
MARC2
Tbio
Novelty:  0.05210077
Score:  0.848
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.827
Data Source:  STRINGDB
PEX19
Tbio
Novelty:  0.00605342
Score:  0.793
Data Source:  STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
Score:  0.774
Data Source:  STRINGDB
TNNT1
Tbio
Novelty:  0.00072003
Score:  0.726
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Molybdenum cofactor biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Molybdenum cofactor biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
2
48.5
mean platelet volume
1
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
48.5
mean platelet volume
2
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
molybdenum cofactor synthesis 2
VGNC:4088
462369
Macaque
molybdenum cofactor synthesis 2
703689
Mouse
MGI:1336894
17434
Rat
RGD:1359477
294753
Dog
molybdenum cofactor synthesis 2
VGNC:43306
479337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
molybdenum cofactor synthesis 2
Macaque
molybdenum cofactor synthesis 2
Mouse
Rat
Dog
molybdenum cofactor synthesis 2
Publication Statistics
PubMed Score 35.34
PubMed score by year
PubTator Score 17.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title