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Tbio
ZBED1
Zinc finger BED domain-containing protein 1

Protein Summary
Description
Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381218
  • ENSP00000370616
  • ENSG00000214717
  • ENST00000381222
  • ENSP00000370620
  • ENST00000381223
  • ENSP00000370621

Symbol
  • ALTE
  • DREF
  • KIAA0785
  • TRAMP
  • ALTE
  • DREF
  • TRAMP
  • hDREF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
virus perturbation
0.9
microRNA
0.79
transcription factor
0.58
small molecule perturbation
0.57


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger BED-type containing 1
100425956
Cow
zinc finger BED-type containing 1
VGNC:37052
539266
Platypus
zinc finger BED-type containing 1
100075143
Anole lizard
zinc finger BED-type containing 1 [Source:HGNC Symbol;Acc:HGNC:447]
Xenopus
zinc finger BED domain-containing protein 1-like
105945140
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger BED-type containing 1
Cow
zinc finger BED-type containing 1
Platypus
zinc finger BED-type containing 1
Anole lizard
zinc finger BED-type containing 1 [Source:HGNC Symbol;Acc:HGNC:447]
Xenopus
zinc finger BED domain-containing protein 1-like
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of chromatin organization proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of chromatin organization proteins
Gene Ontology Terms (13)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (84)
1 – 10 of 84
DHRSX
Tdark
Family: Enzyme
Novelty: 0.24132104
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.781
Data Source: BioPlex,STRINGDB
PDZK1P1
Tdark
p_int: 0.999995563
p_ni: 0.000004436
Data Source: BioPlex
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999898086
p_ni: 0.000101895
p_wrong: 1.9e-8
Data Source: BioPlex
ZNF576
Tdark
Family: TF
Novelty: 13.18548387
p_int: 0.999878556
p_ni: 0.000121444
Score: 0.198
Data Source: BioPlex,STRINGDB
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.999829171
p_ni: 0.000170829
Data Source: BioPlex
CSTF1
Tbio
Novelty: 0.08711712
p_int: 0.999441796
p_ni: 0.000558204
Score: 0.163
Data Source: BioPlex,STRINGDB
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.997437204
p_ni: 0.002562796
Score: 0.202
Data Source: BioPlex,STRINGDB
CREG1
Tbio
Novelty: 0.0071867
p_int: 0.997246013
p_ni: 0.002753987
Score: 0.221
Data Source: BioPlex,STRINGDB
USP22
Tbio
Family: Enzyme
Novelty: 0.01416662
p_int: 0.996011016
p_ni: 0.003988784
p_wrong: 2e-7
Data Source: BioPlex
GATAD2B
Tbio
Family: TF
Novelty: 0.056775
p_int: 0.97236377
p_ni: 0.02763623
Score: 0.232
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  65.34

PubMed score by year
PubTator Score  36.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer