You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HAND1
Heart- and neural crest derivatives-expressed protein 1

Protein Summary
Description
Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231121
  • ENSP00000231121
  • ENSG00000113196

Symbol
  • BHLHA27
  • EHAND
  • Hxt
  • eHand
  • Thing1
  • bHLHa27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
biological process
0.9
phenotype
0.67
PubMedID
0.66
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.01   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.01   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Signaling pathways regulating pluripotency of stem cells
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (38)
1 – 10 of 38
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.971
Data Source: STRINGDB
HAND2
Tbio
Family: TF
Novelty: 0.00478924
Score: 0.946
Data Source: STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.934
Data Source: STRINGDB
FOXP4
Tbio
Family: TF
Novelty: 0.02668451
Score: 0.931
Data Source: STRINGDB
NFATC1
Tbio
Family: TF
Novelty: 0.00130337
Score: 0.906
Data Source: STRINGDB
ELSPBP1
Tbio
Novelty: 0.0179246
Score: 0.9
Data Source: STRINGDB
ADSS
Tchem
Family: Enzyme
Novelty: 0.0126472
Score: 0.9
Data Source: STRINGDB
XYLT1
Tbio
Family: Enzyme
Novelty: 0.00557591
Score: 0.669
Data Source: STRINGDB
CNP
Tbio
Family: Enzyme
Novelty: 0.00566142
Score: 0.639
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.619
Data Source: STRINGDB
Publication Statistics
PubMed Score  164.01

PubMed score by year
PubTator Score  98.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: