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Tclin
NDUFB10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268668
  • ENSP00000268668
  • ENSG00000140990
  • ENST00000543683
  • ENSP00000445086

Symbol
  • PDSW
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.91
transcription factor perturbation
0.8
transcription factor binding site profile
0.79
kinase perturbation
0.71
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
metformin
Rendered image for metformin
Protein-Protein Interactions (178)
1 – 10 of 178
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.998816883
p_ni:  0.001183117
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.997515673
p_ni:  0.002484327
Score:  0.991
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.983419273
p_ni:  0.016580727
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA7
Tclin
Family:  Enzyme
Novelty:  0.16417588
p_int:  0.921593996
p_ni:  0.078406004
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.870669601
p_ni:  0.129330399
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFC2
Tclin
Family:  Enzyme
Novelty:  0.08387385
Score:  0.999
Data Source:  STRINGDB
NDUFA5
Tclin
Family:  Enzyme
Novelty:  0.01763366
Score:  0.999
Data Source:  STRINGDB
NDUFA8
Tclin
Family:  Enzyme
Novelty:  0.05772867
Score:  0.999
Data Source:  STRINGDB
NDUFB2
Tclin
Family:  Enzyme
Novelty:  0.05735054
Score:  0.999
Data Source:  STRINGDB
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
Score:  0.999
Data Source:  STRINGDB
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
92
glomerular filtration rate
2
2
2
78.7
2
3
0
1.1
77.8
hemoglobin measurement
2
1
2
75.6
red blood cell density measurement
1
1
1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
92
glomerular filtration rate
2
78.7
0
1.1
77.8
hemoglobin measurement
2
75.6
red blood cell density measurement
1
71.9
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B10
VGNC:5849
746648
Macaque
NADH:ubiquinone oxidoreductase subunit B10
693482
Mouse
MGI:1915592
68342
Rat
RGD:1310782
681418
Dog
NADH:ubiquinone oxidoreductase subunit B10
VGNC:43699
479887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B10
Macaque
NADH:ubiquinone oxidoreductase subunit B10
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit B10
Publication Statistics
PubMed Score 15.93
PubMed score by year
PubTator Score 2.81
PubTator score by year