Tbio BCL10 B-cell lymphoma/leukemia 10

Protein Summary

Description

Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• O95999
• Q5VUF1

Gene Name

• BCL10

Ensembl ID

• ENST00000370580
• ENSP00000359612
• ENSG00000142867
• ENST00000648566
• ENSP00000498104

Symbol

• CIPER
• CLAP
• CLAP
• mE10
• CIPER
• IMD37
• c-E10
• CARMEN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
virus perturbation	0.98
transcription factor perturbation	0.97
disease perturbation	0.87
molecular function	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 543.83   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 1177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 543.83   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 1177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0