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Tbio
BCL10
B-cell lymphoma/leukemia 10

Protein Summary
Description
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370580
  • ENSP00000359612
  • ENSG00000142867
  • ENST00000648566
  • ENSP00000498104

Symbol
  • CIPER
  • CLAP
  • CLAP
  • mE10
  • CIPER
  • IMD37
  • c-E10
  • CARMEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
0.98
transcription factor perturbation
0.97
disease perturbation
0.87
molecular function
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.23   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 1177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.23   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 1177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Downstream TCR signaling
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (138)
1 – 10 of 138
MALT1
Tchem
Novelty: 0.00413584
Score: 0.999
Data Source: Reactome,STRINGDB
CARD11
Tbio
Family: Enzyme
Novelty: 0.00699463
Score: 0.999
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.00081998
Score: 0.994
Data Source: Reactome,STRINGDB
PRKCQ
Tchem
Family: Kinase
Novelty: 0.00583392
Score: 0.994
Data Source: Reactome,STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00107685
Score: 0.993
Data Source: Reactome,STRINGDB
CARD9
Tbio
Family: Enzyme
Novelty: 0.00825918
Score: 0.992
Data Source: Reactome,STRINGDB
CARD10
Tbio
Family: Enzyme
Novelty: 0.03117188
Score: 0.99
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00159491
Score: 0.977
Data Source: Reactome,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.00091233
Score: 0.965
Data Source: STRINGDB
RIPK2
Tchem
Family: Kinase
Novelty: 0.00667153
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  499.23

PubMed score by year
PubTator Score  319.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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