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Tbio
PTTG1
Securin

Protein Summary
Description
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352433
  • ENSP00000344936
  • ENSG00000164611
  • ENST00000393964
  • ENSP00000377536
  • ENST00000520452
  • ENSP00000430642

Symbol
  • EAP1
  • PTTG
  • TUTR1
  • EAP1
  • PTTG
  • HPTTG
  • TUTR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
disease perturbation
0.96
transcription factor perturbation
0.88
biological process
0.8
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.84   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.84   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (290)
ESPL1
Tbio
Family:  Enzyme
Novelty:  0.00346666
p_int:  0.999997844
p_ni:  0.000002125
p_wrong:  3.2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
p_int:  0.974853682
p_ni:  0.025146318
Score:  0.894
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.929857973
p_ni:  0.070142027
Data Source:  BioPlex
ANAPC11
Tbio
Family:  Enzyme
Novelty:  0.02976518
Score:  0.999
Data Source:  STRINGDB
CDC27
Tbio
Novelty:  0.00589846
Score:  0.999
Data Source:  STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.999
Data Source:  Reactome,STRINGDB
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
Score:  0.999
Data Source:  STRINGDB
FZR1
Tbio
Novelty:  0.01599606
Score:  0.999
Data Source:  STRINGDB
UBE2C
Tbio
Novelty:  0.00731185
Score:  0.997
Data Source:  STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
0
1.3
89.4
3
2
0
1.1
80.3
2
2
0
1.1
80.3
Eczema
2
2
0
1.1
80.3
eosinophil count
2
3
3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
89.4
0
1.1
80.3
0
1.1
80.3
Eczema
0
1.1
80.3
eosinophil count
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pituitary tumor-transforming 1
462238
Macaque
pituitary tumor-transforming 1
696143
Mouse
MGI:1353578
30939
Rat
RGD:68359
64193
Dog
pituitary tumor-transforming 1
479307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pituitary tumor-transforming 1
Macaque
pituitary tumor-transforming 1
Mouse
Rat
Dog
pituitary tumor-transforming 1
Publication Statistics
PubMed Score 339.84
PubMed score by year
PubTator Score 334.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title