Protein Summary
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chr ...more
- ENST00000352433
- ENSP00000344936
- ENSG00000164611
- ENST00000393964
- ENSP00000377536
- ENST00000520452
- ENSP00000430642
- EAP1
- PTTG
- TUTR1
- EAP1
- PTTG
- HPTTG
- TUTR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
disease perturbation | 0.96 | ||
transcription factor perturbation | 0.88 | ||
biological process | 0.8 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.84 (req: < 5)
Gene RIFs: 169 (req: <= 3)
Antibodies: 394 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.84 (req: >= 5)
Gene RIFs: 169 (req: > 3)
Antibodies: 394 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (290)
Nearest Tclin Targets
Pathways (17)
Reactome (12)
KEGG (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdc20 mediated degradation of Securin | ||||
Reactome | APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Reactome | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdc20 mediated degradation of Securin | ||||
APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 2 | 0 | 1.3 | 89.4 | |||||
3 | 2 | 0 | 1.1 | 80.3 | |||||
2 | 2 | 0 | 1.1 | 80.3 | |||||
Eczema | 2 | 2 | 0 | 1.1 | 80.3 | ||||
eosinophil count | 2 | 3 | 3 | 78.4 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 89.4 | |||||
0 | 1.1 | 80.3 | |||||
0 | 1.1 | 80.3 | |||||
Eczema | 0 | 1.1 | 80.3 | ||||
eosinophil count | 3 | 78.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pituitary tumor-transforming 1 | 462238 | ||||||
Macaque | pituitary tumor-transforming 1 | 696143 | ||||||
Mouse | MGI:1353578 | 30939 | ||||||
Rat | RGD:68359 | 64193 | ||||||
Dog | pituitary tumor-transforming 1 | 479307 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pituitary tumor-transforming 1 | |||||
Macaque | pituitary tumor-transforming 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pituitary tumor-transforming 1 | |||||
Publication Statistics
PubMed Score 339.84
PubMed score by year
PubTator Score 334.43
PubTator score by year
Related Publications
Text Mined References (197)
GeneRif Annotations (169)
Items per page:
0 of 0
PMID | Year | Title |
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