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Tbio
APC2
Adenomatous polyposis coli protein 2

Protein Summary
Description
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233607
  • ENSP00000233607
  • ENSG00000115266
  • ENST00000535453
  • ENSP00000442954

Symbol
  • APCL
  • APCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cellular component
0.77
gene perturbation
0.7
cell line
0.66
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.03   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.03   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (20)
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Gastric cancer
KEGG
Cushing syndrome
KEGG
Breast cancer
KEGG
Regulation of actin cytoskeleton
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Gastric cancer
Cushing syndrome
Breast cancer
Regulation of actin cytoskeleton
Signaling pathways regulating pluripotency of stem cells
Gene Ontology Terms (26)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (81)
1 – 10 of 81
CTNNB1
Tchem
Novelty: 0.00008951
Score: 0.987
Data Source: STRINGDB
AXIN2
Tchem
Novelty: 0.0032149
Score: 0.982
Data Source: STRINGDB
AXIN1
Tbio
Novelty: 0.00280253
Score: 0.98
Data Source: STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00104435
Score: 0.922
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.01122537
Score: 0.882
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00460899
Score: 0.872
Data Source: STRINGDB
ARHGEF4
Tbio
Novelty: 0.0297113
Score: 0.865
Data Source: STRINGDB
DVL2
Tbio
Novelty: 0.01142063
Score: 0.865
Data Source: STRINGDB
DVL3
Tbio
Novelty: 0.02234457
Score: 0.865
Data Source: STRINGDB
MAPRE3
Tbio
Novelty: 0.00637656
Score: 0.848
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.03

PubMed score by year
PubTator Score  76.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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