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Tbio
GAS8
Dynein regulatory complex subunit 4

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity). This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268699
  • ENSP00000268699
  • ENSG00000141013
  • ENST00000536122
  • ENSP00000440977

Symbol
  • DRC4
  • GAS11
  • DRC4
  • GAS11
  • CILD33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
disease perturbation
0.56
histone modification site profile
0.55
small molecule perturbation
0.5
phenotype
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.54   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.54   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.902
Data Source:  STRINGDB
CCDC65
Tdark
Novelty:  0.05107666
Score:  0.881
Data Source:  STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
Score:  0.834
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.817
Data Source:  STRINGDB
DNALI1
Tbio
Novelty:  0.13865981
Score:  0.804
Data Source:  STRINGDB
DRC1
Tbio
Novelty:  0.29125683
Score:  0.732
Data Source:  STRINGDB
ZNF276
Tdark
Family:  TF
Novelty:  0.3082638
Score:  0.725
Data Source:  STRINGDB
DRC7
Tdark
Novelty:  0.40606004
Score:  0.719
Data Source:  STRINGDB
CDH10
Tbio
Novelty:  0.06137544
Score:  0.692
Data Source:  STRINGDB
RSPH3
Tdark
Novelty:  0.04470453
Score:  0.691
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Activation of SMO
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
9
17
1
2.5
99.9
suntan
3
9
9
99.8
1
3
0
1.5
97.9
4
3
2
1.4
97.5
3
3
0
1.3
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2.5
99.9
suntan
9
99.8
0
1.5
97.9
2
1.4
97.5
0
1.3
96.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth arrest specific 8
VGNC:5775
454330
Macaque
growth arrest specific 8
701458
Mouse
MGI:1202386
104346
Rat
RGD:1307817
361438
Dog
growth arrest specific 8
VGNC:41120
608663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth arrest specific 8
Macaque
growth arrest specific 8
Mouse
Rat
Dog
growth arrest specific 8
Publication Statistics
PubMed Score 36.54
PubMed score by year
PubTator Score 15.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title