GAS8
Dynein regulatory complex subunit 4
Protein Summary
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity). This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposi ...more
- ENST00000268699
- ENSP00000268699
- ENSG00000141013
- ENST00000536122
- ENSP00000440977
- DRC4
- GAS11
- DRC4
- GAS11
- CILD33
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.62 | ||
disease perturbation | 0.56 | ||
histone modification site profile | 0.55 | ||
small molecule perturbation | 0.5 | ||
phenotype | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.4 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 149 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.4 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 149 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of SMO | ||||
Reactome | Hedgehog 'on' state | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hedgehog | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of SMO | ||||
Hedgehog 'on' state | ||||
Signal Transduction | ||||
Signaling by Hedgehog | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (2)
Components (7)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair color | 10 | 20 | 1 | 2.5 | 99.9 | ||||
suntan | 3 | 9 | 9 | 99.8 | |||||
4 | 3 | 2 | 1.4 | 99.2 | |||||
hair colour measurement | 2 | 6 | 6 | 99.2 | |||||
3 | 3 | 0 | 1.3 | 98.9 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair color | 1 | 2.5 | 99.9 | ||||
suntan | 9 | 99.8 | |||||
2 | 1.4 | 99.2 | |||||
hair colour measurement | 6 | 99.2 | |||||
0 | 1.3 | 98.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | growth arrest specific 8 | VGNC:5775 | 454330 | |||||
Macaque | growth arrest specific 8 | 701458 | ||||||
Mouse | MGI:1202386 | 104346 | ||||||
Rat | RGD:1307817 | 361438 | ||||||
Dog | growth arrest specific 8 | VGNC:41120 | 608663 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | growth arrest specific 8 | |||||
Macaque | growth arrest specific 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth arrest specific 8 | |||||
Publication Statistics
PubMed Score 44.40
PubMed score by year
PubTator Score 15.75
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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