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Tbio
AGR2
Anterior gradient protein 2 homolog

Protein Summary
Description
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419304
  • ENSP00000391490
  • ENSG00000106541

Symbol
  • AG2
  • AG2
  • AG-2
  • HPC8
  • GOB-4
  • HAG-2
  • XAG-2
  • PDIA17
  • HEL-S-116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.88
gene perturbation
0.84
biological term
0.66
small molecule perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.68   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.68   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
LYPD3
Tbio
Novelty:  0.03248533
Score:  0.986
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.847
Data Source:  STRINGDB
AGR3
Tbio
Novelty:  0.0339306
Score:  0.765
Data Source:  STRINGDB
TFF1
Tbio
Novelty:  0.00295014
Score:  0.759
Data Source:  STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.756
Data Source:  STRINGDB
TFF3
Tbio
Novelty:  0.00127103
Score:  0.748
Data Source:  STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
Score:  0.728
Data Source:  STRINGDB
SPDEF
Tbio
Family:  TF
Novelty:  0.00618802
Score:  0.701
Data Source:  STRINGDB
AREG
Tchem
Novelty:  0.0017631
Score:  0.699
Data Source:  STRINGDB
FABP2
Tchem
Novelty:  0.00217814
Score:  0.697
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
51.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anterior gradient 2, protein disulphide isomerase family member
VGNC:7208
463277
Macaque
anterior gradient 2, protein disulphide isomerase family member
709127
Mouse
MGI:1344405
23795
Rat
RGD:1304606
298961
Dog
anterior gradient 2, protein disulphide isomerase family member
VGNC:37715
482333
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anterior gradient 2, protein disulphide isomerase family member
Macaque
anterior gradient 2, protein disulphide isomerase family member
Mouse
Rat
Dog
anterior gradient 2, protein disulphide isomerase family member
Publication Statistics
PubMed Score 219.68
PubMed score by year
PubTator Score 266.44
PubTator score by year
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Related Publications
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PMID
Year
Title