You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
S1PR4
Sphingosine 1-phosphate receptor 4

Protein Summary
Description
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246115
  • ENSP00000246115
  • ENSG00000125910

Symbol
  • EDG6
  • EDG6
  • LPC1
  • S1P4
  • SLP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
protein domain
0.58
disease perturbation
0.56
cell type or tissue
0.51
tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.23   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.23   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 68
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
4
88.5
monocyte count
2
1
2
80.7
leukocyte count
2
2
2
69.8
eosinophil percentage of leukocytes
2
2
3
68.7
mean platelet volume
2
1
2
63.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
88.5
monocyte count
2
80.7
leukocyte count
2
69.8
eosinophil percentage of leukocytes
3
68.7
mean platelet volume
2
63.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (43)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Lysosphingolipid and LPA receptors
Protein-Protein Interactions (315)
1 – 10 of 315
TBC1D24
Tbio
Novelty: 0.0161631
p_int: 0.996766898
p_ni: 0.003057862
p_wrong: 0.00017524
Score: 0.269
Data Source: BioPlex,STRINGDB
PITPNA
Tbio
Novelty: 0.01901136
p_int: 0.77908597
p_ni: 0.22091403
Score: 0.692
Data Source: BioPlex,STRINGDB
CCR7
Tbio
Family: GPCR
Novelty: 0.00084453
Score: 0.972
Data Source: STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
Score: 0.952
Data Source: STRINGDB
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.949
Data Source: STRINGDB
P2RY14
Tchem
Family: GPCR
Novelty: 0.0135462
Score: 0.936
Data Source: STRINGDB
GNA12
Tbio
Novelty: 0.06310884
Score: 0.935
Data Source: STRINGDB
GNA13
Tbio
Novelty: 0.04149138
Score: 0.935
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.935
Data Source: STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.23

PubMed score by year
PubTator Score  34.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: