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Tbio
BMP15
Bone morphogenetic protein 15

Protein Summary
Description
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252677
  • ENSP00000252677
  • ENSG00000130385

Symbol
  • GDF9B
  • ODG2
  • POF4
  • GDF9B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.68
tissue sample
0.68
tissue
0.66
cell line
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.28   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.28   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 15
VGNC:1402
473873
Macaque
bone morphogenetic protein 15
695457
Mouse
MGI:1316745
12155
Rat
RGD:70990
59302
Dog
bone morphogenetic protein 15
VGNC:38477
100856301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 15
Macaque
bone morphogenetic protein 15
Mouse
Rat
Dog
bone morphogenetic protein 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95972-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Protein-Protein Interactions (183)
1 – 10 of 183
AMD1
Tchem
Family: Enzyme
Novelty: 0.00231813
p_int: 0.999389016
p_ni: 0.000610984
Score: 0.204
Data Source: BioPlex,STRINGDB
DCAF6
Tbio
Novelty: 0.01269552
p_int: 0.985867847
p_ni: 0.014132153
Score: 0.294
Data Source: BioPlex,STRINGDB
HECTD1
Tbio
Family: Enzyme
Novelty: 0.28016112
p_int: 0.975807196
p_ni: 0.024192804
Score: 0.223
Data Source: BioPlex,STRINGDB
FAM20C
Tbio
Family: Enzyme
Novelty: 0.00318966
Score: 0.941
Data Source: STRINGDB
FSTL3
Tbio
Novelty: 0.01238701
Score: 0.922
Data Source: STRINGDB
SPP1
Tbio
Novelty: 0.00014418
Score: 0.919
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.918
Data Source: STRINGDB
IGFBP4
Tchem
Novelty: 0.00286837
Score: 0.917
Data Source: STRINGDB
IGFBP7
Tbio
Novelty: 0.00249209
Score: 0.914
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  291.28

PubMed score by year
PubTator Score  117.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer