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Tbio
CD160
CD160 antigen

Protein Summary
Description
Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372). May provide a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon binding to HLA-G may control angiogenesis in immune privileged sites (PubMed:16809620). CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its exp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235933
  • ENSP00000235933
  • ENSG00000117281
  • ENST00000369288
  • ENSP00000358294

Symbol
  • BY55
  • NK1
  • BY55
  • NK28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
tissue sample
0.56
tissue
0.53
cell type or tissue
0.52
cell line
0.51


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.22   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 565   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.22   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 565   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
30.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
30.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD160 molecule
VGNC:11306
469828
Macaque
CD160 molecule
696832
Mouse
MGI:1860383
54215
Rat
RGD:1563598
502585
Dog
CD160 molecule
VGNC:38930
483158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD160 molecule
Macaque
CD160 molecule
Mouse
Rat
Dog
CD160 molecule
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (164)
1 – 10 of 164
CLSTN1
Tbio
Novelty: 0.04056624
p_int: 0.999932199
p_ni: 0.000067801
Data Source: BioPlex
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
p_int: 0.999839851
p_ni: 0.000023567
p_wrong: 0.000136582
Data Source: BioPlex
CELSR3
Tbio
Family: GPCR
Novelty: 0.02705624
p_int: 0.998471472
p_ni: 0.00152813
p_wrong: 3.98e-7
Data Source: BioPlex
FAT4
Tbio
Novelty: 0.01739918
p_int: 0.997962961
p_ni: 0.002037035
p_wrong: 4e-9
Data Source: BioPlex
FAT1
Tbio
Novelty: 0.00340342
p_int: 0.997495992
p_ni: 0.002504008
Data Source: BioPlex
TGFBR3
Tbio
Novelty: 0.0077307
p_int: 0.996332215
p_ni: 0.003652337
p_wrong: 0.000015448
Data Source: BioPlex
ITGA6
Tbio
Novelty: 0.00217985
p_int: 0.996322998
p_ni: 0.003677002
Data Source: BioPlex
DHFR2
Tbio
Family: Enzyme
Novelty: 0.02374466
p_int: 0.995971509
p_ni: 0.004021465
p_wrong: 0.000007025
Data Source: BioPlex
ADGRV1
Tbio
Family: GPCR
Novelty: 0.01398129
p_int: 0.995596199
p_ni: 0.004403801
Data Source: BioPlex
CDH23
Tbio
Novelty: 0.00588227
p_int: 0.994915452
p_ni: 0.005043698
p_wrong: 0.000040851
Data Source: BioPlex
Publication Statistics
PubMed Score  65.22

PubMed score by year
PubTator Score  58.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer