Protein Summary
Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372). May provide a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon binding to HLA-G may control angiogenesis in immune privileged sites (PubMed:16809620). CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its exp ...more
- ENST00000235933
- ENSP00000235933
- ENSG00000117281
- ENST00000369288
- ENSP00000358294
- BY55
- NK1
- BY55
- NK28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.76 | ||
tissue sample | 0.56 | ||
tissue | 0.53 | ||
cell type or tissue | 0.52 | ||
cell line | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.65 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 565 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.65 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 565 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (164)
LOXL1
Family: Enzyme
Novelty: 0.00479897
p_int: 0.999839851
p_ni: 0.000023567
p_wrong: 0.000136582
Data Source: BioPlex
CELSR3
Family: GPCR
Novelty: 0.02705624
p_int: 0.998471472
p_ni: 0.00152813
p_wrong: 3.98e-7
Data Source: BioPlex
TGFBR3
Novelty: 0.0077307
p_int: 0.996332215
p_ni: 0.003652337
p_wrong: 0.000015448
Data Source: BioPlex
DHFR2
Family: Enzyme
Novelty: 0.02374466
p_int: 0.995971509
p_ni: 0.004021465
p_wrong: 0.000007025
Data Source: BioPlex
ADGRV1
Family: GPCR
Novelty: 0.01398129
p_int: 0.995596199
p_ni: 0.004403801
Data Source: BioPlex
CDH23
Novelty: 0.00588227
p_int: 0.994915452
p_ni: 0.005043698
p_wrong: 0.000040851
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 8 | 8 | 12 | 3.3 | 99.2 | ||||
uric acid measurement | 4 | 4 | 7 | 93.1 | |||||
diastolic blood pressure | 1 | 1 | 1 | 39.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 28.1 | |||||
1 | 1 | 0 | 1.1 | 26.6 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 12 | 3.3 | 99.2 | ||||
uric acid measurement | 7 | 93.1 | |||||
diastolic blood pressure | 1 | 39.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 28.1 | |||||
0 | 1.1 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD160 molecule | VGNC:11306 | 469828 | |||||
Macaque | CD160 molecule | 696832 | ||||||
Mouse | MGI:1860383 | 54215 | ||||||
Rat | RGD:1563598 | 502585 | ||||||
Dog | CD160 molecule | VGNC:38930 | 483158 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD160 molecule | |||||
Macaque | CD160 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD160 molecule | |||||
Publication Statistics
PubMed Score 69.65
PubMed score by year
PubTator Score 58.82
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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