Tbio CD160 CD160 antigen

Protein Summary

Description

Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372). May provide a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon binding to HLA-G may control angiogenesis in immune privileged sites (PubMed:16809620). CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95971

Gene Name

• CD160

Ensembl ID

• ENST00000235933
• ENSP00000235933
• ENSG00000117281
• ENST00000369288
• ENSP00000358294

Symbol

• BY55
• NK1
• BY55
• NK28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.76
tissue sample	0.56
tissue	0.53
cell type or tissue	0.52
cell line	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.95   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 565   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.95   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 565   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0