Protein Summary
Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372). May provide a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon binding to HLA-G may control angiogenesis in immune privileged sites (PubMed:16809620). CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its exp ...more
- ENST00000235933
- ENSP00000235933
- ENSG00000117281
- ENST00000369288
- ENSP00000358294
- BY55
- NK1
- BY55
- NK28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.76 | ||
tissue sample | 0.56 | ||
tissue | 0.53 | ||
cell type or tissue | 0.52 | ||
cell line | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.65 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 565 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.65 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 565 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (164)
LOXL1
Family: Enzyme
Novelty: 0.00479897
p_int: 0.999839851
p_ni: 0.000023567
p_wrong: 0.000136582
Data Source: BioPlex
CELSR3
Family: GPCR
Novelty: 0.02705624
p_int: 0.998471472
p_ni: 0.00152813
p_wrong: 3.98e-7
Data Source: BioPlex
TGFBR3
Novelty: 0.0077307
p_int: 0.996332215
p_ni: 0.003652337
p_wrong: 0.000015448
Data Source: BioPlex
DHFR2
Family: Enzyme
Novelty: 0.02374466
p_int: 0.995971509
p_ni: 0.004021465
p_wrong: 0.000007025
Data Source: BioPlex
ADGRV1
Family: GPCR
Novelty: 0.01398129
p_int: 0.995596199
p_ni: 0.004403801
Data Source: BioPlex
CDH23
Novelty: 0.00588227
p_int: 0.994915452
p_ni: 0.005043698
p_wrong: 0.000040851
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 8 | 8 | 12 | 3.3 | 99.2 | ||||
uric acid measurement | 4 | 4 | 7 | 93.1 | |||||
diastolic blood pressure | 1 | 1 | 1 | 39.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 28.1 | |||||
1 | 1 | 0 | 1.1 | 26.6 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 12 | 3.3 | 99.2 | ||||
uric acid measurement | 7 | 93.1 | |||||
diastolic blood pressure | 1 | 39.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 28.1 | |||||
0 | 1.1 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD160 molecule | VGNC:11306 | 469828 | |||||
Macaque | CD160 molecule | 696832 | ||||||
Mouse | MGI:1860383 | 54215 | ||||||
Rat | RGD:1563598 | 502585 | ||||||
Dog | CD160 molecule | VGNC:38930 | 483158 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD160 molecule | |||||
Macaque | CD160 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD160 molecule | |||||
Publication Statistics
PubMed Score 69.65
PubMed score by year
PubTator Score 58.82
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
|---|