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Tbio
EFEMP2
EGF-containing fibulin-like extracellular matrix protein 2

Protein Classes
Protein Summary
Description
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307998
  • ENSP00000309953
  • ENSG00000172638
  • ENST00000531972
  • ENSP00000435295

Symbol
  • FBLN4
  • MBP1
  • UPH1
  • FBLN4
  • ARCL1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
hub protein
0.95
viral protein
0.93
virus
0.89
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.69   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.69   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
5
5
98.1
eosinophil count
3
2
3
93.7
glomerular filtration rate
5
3
6
93.1
eosinophil percentage of leukocytes
2
2
2
91.6
uric acid measurement
2
2
2
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
98.1
eosinophil count
3
93.7
glomerular filtration rate
6
93.1
eosinophil percentage of leukocytes
2
91.6
uric acid measurement
2
89.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EGF containing fibulin extracellular matrix protein 2
VGNC:10398
451335
Macaque
EGF containing fibulin extracellular matrix protein 2
721877
Mouse
MGI:1891209
58859
Rat
RGD:1359496
293677
Dog
EGF containing fibulin extracellular matrix protein 2
VGNC:40221
476020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EGF containing fibulin extracellular matrix protein 2
Macaque
EGF containing fibulin extracellular matrix protein 2
Mouse
Rat
Dog
EGF containing fibulin extracellular matrix protein 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95967-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (68)
1 – 10 of 68
MFAP2
Tbio
Novelty:  0.01599653
Score:  0.956
Data Source:  STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
Score:  0.946
Data Source:  STRINGDB
FBLN5
Tbio
Novelty:  0.00599598
Score:  0.941
Data Source:  STRINGDB
FBLN2
Tbio
Novelty:  0.01340024
Score:  0.924
Data Source:  STRINGDB
VTN
Tbio
Family:  TF
Novelty:  0.00046861
Score:  0.921
Data Source:  STRINGDB
FBLN1
Tbio
Novelty:  0.00796703
Score:  0.92
Data Source:  STRINGDB
MFAP4
Tbio
Novelty:  0.02023782
Score:  0.917
Data Source:  STRINGDB
EFEMP1
Tbio
Novelty:  0.00574779
Score:  0.911
Data Source:  STRINGDB
MFAP1
Tbio
Novelty:  0.15311456
Score:  0.9
Data Source:  STRINGDB
MFAP3
Tdark
Novelty:  0.55512255
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  73.69

PubMed score by year
PubTator Score  48.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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