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Tbio
TBX6
T-box transcription factor TBX6

Protein Summary
Description
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279386
  • ENSP00000279386
  • ENSG00000149922
  • ENST00000395224
  • ENSP00000378650
  • ENST00000553607
  • ENSP00000461223
  • ENST00000567664
  • ENSP00000460425

Symbol
  • SCDO5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
transcription factor perturbation
0.68
cell type or tissue
0.66
tissue sample
0.65
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.86   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.86   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
3
6
94.7
body mass index
4
4
4
94.4
mean corpuscular volume
3
2
3
94
red blood cell density measurement
2
1
2
87.3
mean corpuscular hemoglobin concentration
1
1
1
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
6
94.7
body mass index
4
94.4
mean corpuscular volume
3
94
red blood cell density measurement
2
87.3
mean corpuscular hemoglobin concentration
1
87
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 6
VGNC:5930
467944
Macaque
T-box 6
710353
Mouse
MGI:102539
21389
Rat
RGD:1307716
365371
Dog
T-box 6
VGNC:54076
489948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 6
Macaque
T-box 6
Mouse
Rat
Dog
T-box 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95947-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neovascularisation processes
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Neovascularisation processes
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (72)
1 – 10 of 72
MSGN1
Tbio
Family:  TF
Novelty:  0.10117512
Score:  0.827
Data Source:  STRINGDB
HES7
Tbio
Family:  TF
Novelty:  0.02014919
Score:  0.825
Data Source:  STRINGDB
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.802
Data Source:  STRINGDB
FGF8
Tbio
Novelty:  0.00155113
Score:  0.752
Data Source:  STRINGDB
MEOX1
Tbio
Family:  TF
Novelty:  0.02978667
Score:  0.698
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.687
Data Source:  STRINGDB
MIXL1
Tbio
Family:  TF
Novelty:  0.0196256
Score:  0.682
Data Source:  STRINGDB
RIPPLY2
Tdark
Novelty:  0.16163153
Score:  0.672
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.672
Data Source:  STRINGDB
RIPPLY1
Tdark
Novelty:  0.11705603
Score:  0.66
Data Source:  STRINGDB
Publication Statistics
PubMed Score  104.86

PubMed score by year
PubTator Score  27.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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