Tbio TBX6 T-box transcription factor TBX6

Protein Summary

Description

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• O95947
• Q8TAS4
• Q9HA44
• T-box protein 6

Gene Name

• TBX6

Ensembl ID

• ENST00000279386
• ENSP00000279386
• ENSG00000149922
• ENST00000395224
• ENSP00000378650
• ENST00000553607
• ENSP00000461223
• ENST00000567664
• ENSP00000460425

Symbol

• SCDO5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.85
transcription factor perturbation	0.68
cell type or tissue	0.66
tissue sample	0.65
histone modification site profile	0.64

Protein Classes

PANTHER Classes

Protein / Transcription Factor / T-box Transcription Factor Tbx6

Protein / Nucleic Acid Binding / T-box Transcription Factor Tbx6

Protein / ... / Rel Homology Transcription Factor / T-box Transcription Factor Tbx6

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / T-box Transcription Factor Tbx6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.56   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.56   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0