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Tbio
TBX18
T-box transcription factor TBX18

Protein Summary
Description
Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369663
  • ENSP00000358677
  • ENSG00000112837

Symbol
  • CAKUT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
molecular function
0.86
gene perturbation
0.83
transcription factor binding site profile
0.7
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.18   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.18   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
TBX20
Tbio
Family:  TF
Novelty:  0.01290983
p_int:  0.999264334
p_ni:  9.34e-7
p_wrong:  0.000734732
Data Source:  BioPlex
PAPSS2
Tbio
Family:  Enzyme
Novelty:  0.01538798
p_int:  0.974389559
p_ni:  0.025531269
p_wrong:  0.000079172
Data Source:  BioPlex
TCF21
Tbio
Family:  TF
Novelty:  0.0005831
Score:  0.874
Data Source:  STRINGDB
WT1
Tbio
Family:  TF
Novelty:  0.00034353
Score:  0.832
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.818
Data Source:  STRINGDB
SHOX2
Tbio
Family:  TF
Novelty:  0.01090989
Score:  0.796
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.774
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.772
Data Source:  STRINGDB
IRX4
Tbio
Family:  TF
Novelty:  0.0383218
Score:  0.766
Data Source:  STRINGDB
HCN4
Tclin
Family:  IC
Novelty:  0.0021957
Score:  0.736
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
3
3
81.9
BMI-adjusted waist circumference
2
2
2
58.9
waist-hip ratio
2
2
3
50.5
pulse pressure measurement
1
1
1
12.6
balding measurement
1
1
1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
81.9
BMI-adjusted waist circumference
2
58.9
waist-hip ratio
3
50.5
pulse pressure measurement
1
12.6
balding measurement
1
10.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 18
VGNC:3741
462861
Macaque
T-box 18
696007
Mouse
MGI:1923615
76365
Rat
RGD:1309856
315870
Dog
T-box 18
481903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 18
Macaque
T-box 18
Mouse
Rat
Dog
T-box 18
Publication Statistics
PubMed Score 90.18
PubMed score by year
PubTator Score 24.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title