TGM6
Protein-glutamine gamma-glutamyltransferase 6
Protein Summary
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000202625
- ENSP00000202625
- ENSG00000166948
- ENST00000381423
- ENSP00000370831
- TGM3L
- TG6
- TGY
- SCA35
- TGM3L
- dJ734P14.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
cell type or tissue | 0.74 | ||
gene perturbation | 0.56 | ||
tissue | 0.55 | ||
cell line | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.77 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 65 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.77 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 65 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0