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Tchem
CBX7
Chromobox protein homolog 7

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216133
  • ENSP00000216133
  • ENSG00000100307
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
PubMedID
0.81
protein domain
0.73
transcription factor binding site profile
0.73
histone modification site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.39   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.39   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (24)
1 – 10 of 24
CHEMBL3939958
chemical structure image
CHEMBL3780251
chemical structure image
CHEMBL3780712
chemical structure image
CHEMBL3898460
chemical structure image
CHEMBL3889586
chemical structure image
CHEMBL3933207
chemical structure image
CHEMBL3969494
chemical structure image
CHEMBL3942693
chemical structure image
CHEMBL3925993
chemical structure image
CHEMBL3937936
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
98.2
lymphocyte count
3
1
3
83.3
myeloid white cell count
1
1
1
78
red blood cell density measurement
1
1
1
67.3
monocyte count
1
1
1
53.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.2
lymphocyte count
3
83.3
myeloid white cell count
1
78
red blood cell density measurement
1
67.3
monocyte count
1
53.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromobox 7
VGNC:5239
458843
Macaque
chromobox 7
703056
Dog
chromobox 7
VGNC:38768
481247
Cow
chromobox 7
VGNC:26820
525770
Opossum
chromobox 7 [Source:HGNC Symbol;Acc:HGNC:1557]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromobox 7
Macaque
chromobox 7
Dog
chromobox 7
Cow
chromobox 7
Opossum
chromobox 7 [Source:HGNC Symbol;Acc:HGNC:1557]
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95931-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (103)
1 – 10 of 103
USP20
Tbio
Family: Enzyme
Novelty: 0.06647037
p_int: 0.999997127
p_ni: 0.000002868
p_wrong: 5e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
PHC1
Tbio
Novelty: 0.01530622
p_int: 0.999991097
p_ni: 9.2e-8
p_wrong: 0.000008811
Score: 0.994
Data Source: BioPlex,STRINGDB
PHC3
Tbio
Novelty: 0.00091911
p_int: 0.999972263
p_ni: 0.000027574
p_wrong: 1.62e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
PCGF1
Tbio
Novelty: 0.06481661
p_int: 0.999972204
p_ni: 0.000027795
Score: 0.981
Data Source: BioPlex,STRINGDB
PCGF2
Tbio
Novelty: 0.02148755
p_int: 0.999956267
p_ni: 7.8e-8
p_wrong: 0.000043655
Score: 0.995
Data Source: BioPlex,STRINGDB
BMI1
Tbio
Novelty: 0.00158043
p_int: 0.999948989
p_ni: 0.000051011
Score: 0.987
Data Source: BioPlex,STRINGDB
PHC2
Tbio
Novelty: 0.01943349
p_int: 0.999817324
p_ni: 0.000182674
p_wrong: 2e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.999690415
p_ni: 0.000309585
Score: 0.979
Data Source: BioPlex,STRINGDB
PCGF3
Tbio
Novelty: 0.14226976
p_int: 0.99910239
p_ni: 0.000479685
p_wrong: 0.000417925
Score: 0.97
Data Source: BioPlex,STRINGDB
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
p_int: 0.996872127
p_ni: 0.003127873
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  76.39

PubMed score by year
PubTator Score  40.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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