Tbio SYF2 Pre-mRNA-splicing factor SYF2

Protein Summary

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95926
• Q5TH73

Gene Name

• SYF2

Ensembl ID

• ENST00000236273
• ENSP00000236273
• ENSG00000117614
• ENST00000354361
• ENSP00000346330

Symbol

• CBPIN
• GCIPIP
• P29
• CBPIN
• NTC31
• fSAP29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
transcription factor binding site profile	0.87
histone modification site profile	0.84
tissue sample	0.71
cell type or tissue	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.33   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.33   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (245)

Explore Interacting Targets

1 – 10 of 245

• See Interactions on String-DB

GPATCH1

Tdark

Novelty:  0.93318176

p_int:  0.999993109

p_ni:  0.000006891

Score:  0.816

Data Source:  BioPlex,STRINGDB

PPIE

Tbio

Family:  Enzyme

Novelty:  0.01586411

p_int:  0.999988658

p_ni:  0.000011342

Score:  0.978

Data Source:  BioPlex,STRINGDB

WDR83

Tbio

Novelty:  0.11602568

p_int:  0.999978223

p_ni:  0.000021777

Score:  0.656

Data Source:  BioPlex,STRINGDB

TSSC4

Tdark

Novelty:  0.17064786

p_int:  0.999955161

p_ni:  0.000044839

Score:  0.782

Data Source:  BioPlex,STRINGDB

CWF19L2

Tdark

Novelty:  0.80210985

p_int:  0.999951036

p_ni:  0.000048964

Score:  0.833

Data Source:  BioPlex,STRINGDB

USB1

Tbio

Family:  Enzyme

Novelty:  0.01677996

p_int:  0.999941377

p_ni:  0.00005862

p_wrong:  3e-9

Score:  0.809

Data Source:  BioPlex,STRINGDB

DHX35

Tdark

Family:  Enzyme

Novelty:  0.26052594

p_int:  0.999935841

p_ni:  0.000064159

Score:  0.803

Data Source:  BioPlex,STRINGDB

CDC40

Tbio

Novelty:  0.03139044

p_int:  0.999908178

p_ni:  0.000091821

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

AQR

Tbio

Novelty:  0.00434312

p_int:  0.999881432

p_ni:  0.000118568

Score:  0.997

Data Source:  BioPlex,STRINGDB

CRNKL1

Tbio

Novelty:  0.10274174

p_int:  0.999849304

p_ni:  0.000150696

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (1)

Components (7)

Processes (6)

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10

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GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	2	3	3		90.6
platelet crit	EFO_0007985	2	2	2		89.7
platelet count	EFO_0004309	1	2	2		89.1
Alopecia	Orphanet_79364	1	3	3		88.7
mean reticulocyte volume	EFO_0010701	1	1	1		87.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	3		90.6
platelet crit	EFO_0007985	2		89.7
platelet count	EFO_0004309	2		89.1
Alopecia	Orphanet_79364	3		88.7
mean reticulocyte volume	EFO_0010701	1		87.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Isopeptide bond
mRNA processing
mRNA splicing
Nucleus
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
androgenetic alopecia
apolipoprotein B measurement
balding measurement
bilirubin measurement
blood sedimentation
HbA1c measurement
low density lipoprotein cholesterol measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SYF2 pre-mRNA splicing factor	VGNC:8512	456634
Macaque	SYF2 pre-mRNA splicing factor		719564
Mouse	SYF2 homolog, RNA splicing factor (S. cerevisiae)	MGI:1915842	68592
Rat	SYF2 pre-mRNA-splicing factor	RGD:621592	170933
Dog	SYF2 pre-mRNA splicing factor		478184

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SYF2 pre-mRNA splicing factor
Macaque	SYF2 pre-mRNA splicing factor
Mouse	SYF2 homolog, RNA splicing factor (S. cerevisiae)
Rat	SYF2 pre-mRNA-splicing factor
Dog	SYF2 pre-mRNA splicing factor

Publication Statistics

PubMed Score 18.33

PubMed score by year

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PubTator Score 99.86

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title