Tbio SLC16A8 Monocarboxylate transporter 3

Protein Summary

Description

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

Uniprot Accession IDs

• O95907
• Q9UBE2
• MCT 3

Gene Name

• SLC16A8

Ensembl ID

• ENST00000320521
• ENSP00000321735
• ENSG00000100156

Symbol

• MCT3
• MCT3
• REMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.72
molecular function	0.6
tissue	0.53
pathway	0.52
tissue sample	0.48

Protein Classes

PANTHER Classes

Protein / Transporter / Monocarboxylate Transporter 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc16 Family Of Monocarboxylate Transporters / Monocarboxylate Transporter 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.22   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.22   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0