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Tdark
TRUB2
Mitochondrial mRNA pseudouridine synthase TRUB2

Protein Classes
Protein Summary
Description
Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372890
  • ENSP00000361982
  • ENSG00000167112

Symbol
  • CLONE24922
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
histone modification site profile
0.78
disease perturbation
0.74
virus perturbation
0.68
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.71   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.71   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
4
6
77.5
body height
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
77.5
body height
1
44.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TruB pseudouridine synthase family member 2
VGNC:10115
464767
Macaque
TruB pseudouridine synthase family member 2
717619
Mouse
MGI:2442186
227682
Rat
RGD:1359394
366012
Dog
TruB pseudouridine synthase family member 2
VGNC:47889
608574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TruB pseudouridine synthase family member 2
Macaque
TruB pseudouridine synthase family member 2
Mouse
Rat
Dog
TruB pseudouridine synthase family member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95900-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (189)
1 – 10 of 189
FYCO1
Tbio
Novelty:  0.06181219
p_int:  0.999999887
p_ni:  1.13e-7
Data Source:  BioPlex
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.996878972
p_ni:  0.003121028
Data Source:  BioPlex
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.994035237
p_ni:  0.005964763
Data Source:  BioPlex
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.993716799
p_ni:  0.006283201
Data Source:  BioPlex
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
p_int:  0.993332265
p_ni:  0.006667735
Score:  0.897
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.992634827
p_ni:  0.007365173
Score:  0.355
Data Source:  BioPlex,STRINGDB
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.992544788
p_ni:  0.007455212
Data Source:  BioPlex
FASTKD2
Tbio
Family:  Enzyme
Novelty:  0.12614412
p_int:  0.990886094
p_ni:  0.009113906
Score:  0.914
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.990301254
p_ni:  0.009698746
Score:  0.353
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.989902884
p_ni:  0.010097116
Data Source:  BioPlex
Publication Statistics
PubMed Score  1.71

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer