TXNDC12
Thioredoxin domain-containing protein 12
Protein Classes
Protein Summary
Possesses significant protein thiol-disulfide oxidase activity. This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
- ENST00000371626
- ENSP00000360688
- ENSG00000117862
- TLP19
- AG1
- AGR1
- ERP16
- ERP18
- ERP19
- TLP19
- hAG-1
- PDIA16
- hTLP19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.83 | ||
histone modification site profile | 0.72 | ||
cell type or tissue | 0.65 | ||
virus perturbation | 0.64 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.22 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.22 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thioredoxin domain containing 12 | VGNC:9409 | 100610643 | |||||
Mouse | MGI:1913323 | 66073 | ||||||
Rat | RGD:1305960 | 298370 | ||||||
Dog | thioredoxin domain containing 12 | VGNC:48011 | 609843 | |||||
Horse | thioredoxin domain containing 12 | VGNC:24677 | 100062254 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thioredoxin domain containing 12 | |||||
Mouse | ||||||
Rat | ||||||
Dog | thioredoxin domain containing 12 | |||||
Horse | thioredoxin domain containing 12 | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (2)
KEGG (2)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Glutathione metabolism | ||||
KEGG | Metabolic pathways | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glutathione metabolism | ||||
Metabolic pathways | ||||
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (84)
1 – 10 of 84
TUBGCP4
Novelty: 0.04549455
p_int: 0.999948013
p_ni: 0.000051987
Score: 0.736
Data Source: BioPlex,STRINGDB
TUBGCP5
Novelty: 0.04863776
p_int: 0.999943078
p_ni: 0.000056904
p_wrong: 1.7e-8
Score: 0.859
Data Source: BioPlex,STRINGDB
MZT2A
Novelty: 1.66535264
p_int: 0.999929875
p_ni: 0.000002088
p_wrong: 0.000068037
Score: 0.818
Data Source: BioPlex,STRINGDB
TUBGCP6
Novelty: 0.05801955
p_int: 0.999919276
p_ni: 0.000080724
Score: 0.819
Data Source: BioPlex,STRINGDB
MZT2B
Novelty: 0.69469786
p_int: 0.999504879
p_ni: 0.000494931
p_wrong: 1.9e-7
Score: 0.827
Data Source: BioPlex,STRINGDB
TUBGCP3
Novelty: 0.0221126
p_int: 0.99879529
p_ni: 0.00120471
Score: 0.71
Data Source: BioPlex,STRINGDB
TUBGCP2
Novelty: 0.01856674
p_int: 0.998394955
p_ni: 0.001605045
Score: 0.774
Data Source: BioPlex,STRINGDB
NME7
Family: Enzyme
Novelty: 0.08546782
p_int: 0.996372585
p_ni: 0.003627415
p_wrong: 1e-9
Score: 0.676
Data Source: BioPlex,STRINGDB
TUBG1
Novelty: 0.02252882
p_int: 0.993529484
p_ni: 0.006470516
Score: 0.825
Data Source: BioPlex,STRINGDB
TM2D3
Novelty: 0.09408834
p_int: 0.865975176
p_ni: 0.134024824
Data Source: BioPlex
Publication Statistics
PubMed Score 72.22
PubMed score by year
PubTator Score 50.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: