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Tbio
TXNDC12
Thioredoxin domain-containing protein 12

Protein Summary
Description
Possesses significant protein thiol-disulfide oxidase activity. This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371626
  • ENSP00000360688
  • ENSG00000117862

Symbol
  • TLP19
  • AG1
  • AGR1
  • ERP16
  • ERP18
  • ERP19
  • TLP19
  • hAG-1
  • PDIA16
  • hTLP19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.83
histone modification site profile
0.72
cell type or tissue
0.65
virus perturbation
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.22   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.22   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 12
VGNC:9409
100610643
Mouse
MGI:1913323
66073
Rat
RGD:1305960
298370
Dog
thioredoxin domain containing 12
VGNC:48011
609843
Horse
thioredoxin domain containing 12
VGNC:24677
100062254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 12
Mouse
Rat
Dog
thioredoxin domain containing 12
Horse
thioredoxin domain containing 12
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95881-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (84)
1 – 10 of 84
TUBGCP4
Tbio
Novelty: 0.04549455
p_int: 0.999948013
p_ni: 0.000051987
Score: 0.736
Data Source: BioPlex,STRINGDB
TUBGCP5
Tbio
Novelty: 0.04863776
p_int: 0.999943078
p_ni: 0.000056904
p_wrong: 1.7e-8
Score: 0.859
Data Source: BioPlex,STRINGDB
MZT2A
Tdark
Novelty: 1.66535264
p_int: 0.999929875
p_ni: 0.000002088
p_wrong: 0.000068037
Score: 0.818
Data Source: BioPlex,STRINGDB
TUBGCP6
Tbio
Novelty: 0.05801955
p_int: 0.999919276
p_ni: 0.000080724
Score: 0.819
Data Source: BioPlex,STRINGDB
MZT2B
Tdark
Novelty: 0.69469786
p_int: 0.999504879
p_ni: 0.000494931
p_wrong: 1.9e-7
Score: 0.827
Data Source: BioPlex,STRINGDB
TUBGCP3
Tbio
Novelty: 0.0221126
p_int: 0.99879529
p_ni: 0.00120471
Score: 0.71
Data Source: BioPlex,STRINGDB
TUBGCP2
Tbio
Novelty: 0.01856674
p_int: 0.998394955
p_ni: 0.001605045
Score: 0.774
Data Source: BioPlex,STRINGDB
NME7
Tbio
Family: Enzyme
Novelty: 0.08546782
p_int: 0.996372585
p_ni: 0.003627415
p_wrong: 1e-9
Score: 0.676
Data Source: BioPlex,STRINGDB
TUBG1
Tbio
Novelty: 0.02252882
p_int: 0.993529484
p_ni: 0.006470516
Score: 0.825
Data Source: BioPlex,STRINGDB
TM2D3
Tbio
Novelty: 0.09408834
p_int: 0.865975176
p_ni: 0.134024824
Data Source: BioPlex
Publication Statistics
PubMed Score  72.22

PubMed score by year
PubTator Score  50.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer