TXNDC12
Thioredoxin domain-containing protein 12
Protein Summary
Possesses significant protein thiol-disulfide oxidase activity. This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
- ENST00000371626
- ENSP00000360688
- ENSG00000117862
- TLP19
- AG1
- AGR1
- ERP16
- ERP18
- ERP19
- TLP19
- hAG-1
- PDIA16
- hTLP19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.83 | ||
histone modification site profile | 0.72 | ||
cell type or tissue | 0.65 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.35 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.35 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0