Tbio TXNDC12 Thioredoxin domain-containing protein 12

Protein Summary

Description

Possesses significant protein thiol-disulfide oxidase activity. This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• O95881
• B3KQS0
• Q5T1T4
• Q96H50

Gene Name

• TXNDC12

Ensembl ID

• ENST00000371626
• ENSP00000360688
• ENSG00000117862

Symbol

• TLP19
• AG1
• AGR1
• ERP16
• ERP18
• ERP19
• TLP19
• hAG-1
• PDIA16
• hTLP19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
transcription factor binding site profile	0.83
histone modification site profile	0.72
cell type or tissue	0.65
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Surfactant / Thioredoxin Domain-containing Protein 12

Protein / Oxidoreductase / Reductase / Thioredoxin Domain-containing Protein 12

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Thioredoxin Domain-containing Protein 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.91   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.91   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

TUBGCP4

Tbio

Novelty:  0.04549455

p_int:  0.999948013

p_ni:  0.000051987

Score:  0.736

Data Source:  BioPlex,STRINGDB

TUBGCP5

Tbio

Novelty:  0.04863776

p_int:  0.999943078

p_ni:  0.000056904

p_wrong:  1.7e-8

Score:  0.859

Data Source:  BioPlex,STRINGDB

MZT2A

Tdark

Novelty:  1.66535264

p_int:  0.999929875

p_ni:  0.000002088

p_wrong:  0.000068037

Score:  0.818

Data Source:  BioPlex,STRINGDB

TUBGCP6

Tbio

Novelty:  0.05801955

p_int:  0.999919276

p_ni:  0.000080724

Score:  0.819

Data Source:  BioPlex,STRINGDB

MZT2B

Tdark

Novelty:  0.69469786

p_int:  0.999504879

p_ni:  0.000494931

p_wrong:  1.9e-7

Score:  0.827

Data Source:  BioPlex,STRINGDB

TUBGCP3

Tbio

Novelty:  0.0221126

p_int:  0.99879529

p_ni:  0.00120471

Score:  0.71

Data Source:  BioPlex,STRINGDB

TUBGCP2

Tbio

Novelty:  0.01856674

p_int:  0.998394955

p_ni:  0.001605045

Score:  0.774

Data Source:  BioPlex,STRINGDB

NME7

Tbio

Family:  Enzyme

Novelty:  0.08546782

p_int:  0.996372585

p_ni:  0.003627415

p_wrong:  1e-9

Score:  0.676

Data Source:  BioPlex,STRINGDB

TUBG1

Tbio

Novelty:  0.02252882

p_int:  0.993529484

p_ni:  0.006470516

Score:  0.825

Data Source:  BioPlex,STRINGDB

TM2D3

Tbio

Novelty:  0.09408834

p_int:  0.865975176

p_ni:  0.134024824

Data Source:  BioPlex

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Upstream (1)

1 – 1 of 1

GSR

Tclin

Family:  Enzyme

KEGG Distance:  2

Common Pathways:  2

1: Glutathione metabolism

2: Metabolic pathways

Pathways (2)

KEGG (2)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Glutathione metabolism	56 targets	path:hsa00480
KEGG	Metabolic pathways	1433 targets	path:hsa01100

Name	Explore in Pharos	Explore in Source
Glutathione metabolism	56 targets	path:hsa00480
Metabolic pathways	1433 targets	path:hsa01100

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (2)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
peptide disulfide oxidoreductase activity	Inferred from Direct Assay (IDA)	MGI
protein-disulfide reductase (glutathione) activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		59
BMI-adjusted hip circumference	EFO_0008039	1	1	1		0.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		59
BMI-adjusted hip circumference	EFO_0008039	1		0.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Oxidoreductase
Redox-active center
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
mean platelet volume

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thioredoxin domain containing 12	VGNC:9409	100610643
Mouse	thioredoxin domain containing 12 (endoplasmic reticulum)	MGI:1913323	66073
Rat	thioredoxin domain containing 12	RGD:1305960	298370
Dog	thioredoxin domain containing 12	VGNC:48011	609843
Horse	thioredoxin domain containing 12	VGNC:24677	100062254

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thioredoxin domain containing 12
Mouse	thioredoxin domain containing 12 (endoplasmic reticulum)
Rat	thioredoxin domain containing 12
Dog	thioredoxin domain containing 12
Horse	thioredoxin domain containing 12

Publication Statistics

PubMed Score 73.91

PubMed score by year

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PubTator Score 50.53

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title