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Tbio
LY6G6C
Lymphocyte antigen 6 complex locus protein G6c

Protein Summary
Description
LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375819
  • ENSP00000364978
  • ENSG00000204421
  • ENST00000383413
  • ENSP00000372905
  • ENSG00000206398
  • ENST00000419939
  • ENSP00000388591
  • ENSG00000235452
  • ENST00000428121
  • ENSP00000411365
  • ENSG00000228250
  • ENST00000428498
  • ENSP00000410398
  • ENSG00000228859
  • ENST00000434915
  • ENSP00000415732
  • ENSG00000236183
  • ENST00000448386
  • ENSP00000409428
  • ENSG00000235925

Symbol
  • C6orf24
  • G6C
  • NG24
  • G6c
  • NG24
  • C6orf24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.69
disease perturbation
0.68
tissue
0.56
transcription factor perturbation
0.54
disease
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
CCDC82
Tdark
Novelty:  0.48211191
p_int:  0.813976912
p_ni:  0.000017427
p_wrong:  0.186005661
Score:  0.622
Data Source:  BioPlex,STRINGDB
LY6G6D
Tbio
Novelty:  0.03244924
Score:  0.97
Data Source:  STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.943
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.942
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.937
Data Source:  STRINGDB
LYPD5
Tdark
Novelty:  0.97576337
Score:  0.936
Data Source:  STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
Score:  0.931
Data Source:  STRINGDB
LYPD2
Tdark
Novelty:  0.55307434
Score:  0.931
Data Source:  STRINGDB
LY6D
Tbio
Novelty:  0.07032941
Score:  0.929
Data Source:  STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (427)
Items per page:
1 – 5 of 427
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
Items per page:
1 – 5 of 427
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lymphocyte antigen 6 family member G6C
716220
Mouse
MGI:2148930
68468
Rat
RGD:1302999
294241
Dog
lymphocyte antigen 6 family member G6C
VGNC:42875
607379
Cow
lymphocyte antigen 6 family member G6C
VGNC:31090
505805
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lymphocyte antigen 6 family member G6C
Mouse
Rat
Dog
lymphocyte antigen 6 family member G6C
Cow
lymphocyte antigen 6 family member G6C
Publication Statistics
PubMed Score 8.40
PubMed score by year
PubTator Score 0.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title