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Tbio
MPIG6B
Megakaryocyte and platelet inhibitory receptor G6b

Protein Summary
Description
Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375804
  • ENSP00000364962
  • ENSG00000204420
  • ENST00000375805
  • ENSP00000364963
  • ENST00000375806
  • ENSP00000364964
  • ENST00000375809
  • ENSP00000364967
  • ENST00000375810
  • ENSP00000364968
  • ENST00000375814
  • ENSP00000364972
  • ENST00000383410
  • ENSP00000372902
  • ENSG00000206396
  • ENST00000383411
  • ENSP00000372903
  • ENST00000383412
  • ENSP00000372904
  • ENST00000400067
  • ENSP00000382940
  • ENST00000400071
  • ENSP00000382944
  • ENST00000411608
  • ENSP00000392961
  • ENSG00000228090
  • ENST00000415728
  • ENSP00000408430
  • ENSG00000224393
  • ENST00000415984
  • ENSP00000394082
  • ENSG00000237459
  • ENST00000417610
  • ENSP00000412747
  • ENSG00000230060
  • ENST00000422012
  • ENSP00000398061
  • ENST00000425998
  • ENSP00000392917
  • ENST00000426729
  • ENSP00000390272
  • ENST00000428302
  • ENSP00000404519
  • ENSG00000231003
  • ENST00000431888
  • ENSP00000390821
  • ENST00000433769
  • ENSP00000413647
  • ENST00000435007
  • ENSP00000401892
  • ENST00000436030
  • ENSP00000406706
  • ENST00000437153
  • ENSP00000412937
  • ENST00000440063
  • ENSP00000388982
  • ENST00000444404
  • ENSP00000415282
  • ENST00000445381
  • ENSP00000396823
  • ENST00000447587
  • ENSP00000416447
  • ENST00000449633
  • ENSP00000388484
  • ENST00000451549
  • ENSP00000395801
  • ENST00000455185
  • ENSP00000414824
  • ENST00000457450
  • ENSP00000395279
  • ENST00000457884
  • ENSP00000391097
  • ENST00000649779
  • ENSP00000497720

Symbol
  • C6orf25
  • G6B
  • G6B-B
  • G6b
  • NG31
  • G6b-B
  • THAMY
  • C6orf25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
 No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.54   (req: < 5)
View Publications
Gene RIFs: 12   (req: <= 3)
View Gene RIFs
Antibodies: 76   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.54   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0