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Tbio
FADS2
Acyl-CoA 6-desaturase

Protein Summary
Description
Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum (PubMed:12713571). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257261
  • ENSP00000257261
  • ENSG00000134824
  • ENST00000278840
  • ENSP00000278840
  • ENST00000521849
  • ENSP00000431091
  • ENST00000522056
  • ENSP00000429500

Symbol
  • D6D
  • DES6
  • TU13
  • FADSD6
  • LLCDL2
  • SLL0262
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
transcription factor perturbation
0.94
phenotype
0.93
gene perturbation
0.92
small molecule perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 585.16   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 585.16   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (95)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
4
3
4
99.4
low density lipoprotein cholesterol measurement
10
13
21
2.6
99.2
total cholesterol measurement
8
11
20
2.2
99.1
triglyceride measurement
15
15
39
3.8
98.9
high density lipoprotein cholesterol measurement
12
12
27
1.9
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
4
99.4
low density lipoprotein cholesterol measurement
21
2.6
99.2
total cholesterol measurement
20
2.2
99.1
triglyceride measurement
39
3.8
98.9
high density lipoprotein cholesterol measurement
27
1.9
98.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid desaturase 2
VGNC:11349
451244
Macaque
fatty acid desaturase 2
719037
Mouse
MGI:1930079
56473
Rat
RGD:68339
83512
Dog
fatty acid desaturase 2
VGNC:40564
483792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid desaturase 2
Macaque
fatty acid desaturase 2
Mouse
Rat
Dog
fatty acid desaturase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95864-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Linoleic acid (LA) metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Linoleic acid (LA) metabolism
Metabolism
Metabolism of lipids
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Protein-Protein Interactions (105)
1 – 10 of 105
ELOVL5
Tbio
Novelty: 0.00536344
Score: 0.986
Data Source: STRINGDB
ACSL1
Tbio
Family: Enzyme
Novelty: 0.00336161
Score: 0.952
Data Source: STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
Score: 0.936
Data Source: STRINGDB
ACSL3
Tbio
Family: Enzyme
Novelty: 0.01772336
Score: 0.933
Data Source: STRINGDB
ACSL5
Tbio
Family: Enzyme
Novelty: 0.00850919
Score: 0.928
Data Source: STRINGDB
ACSL6
Tbio
Family: Enzyme
Novelty: 0.0100317
Score: 0.922
Data Source: STRINGDB
ACSM5
Tbio
Family: Enzyme
Novelty: 0.11562771
Score: 0.92
Data Source: STRINGDB
ACSL4
Tbio
Family: Enzyme
Novelty: 0.0072645
Score: 0.918
Data Source: STRINGDB
ACSBG1
Tbio
Family: Enzyme
Novelty: 0.00381436
Score: 0.916
Data Source: STRINGDB
ACSBG2
Tbio
Family: Enzyme
Novelty: 0.1072938
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score  585.16

PubMed score by year
PubTator Score  367.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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