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Tbio
SNAI1
Zinc finger protein SNAI1

Protein Summary
Description
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDK ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244050
  • ENSP00000244050
  • ENSG00000124216

Symbol
  • SNAH
  • SNA
  • SNAH
  • SNAIL
  • SLUGH2
  • SNAIL1
  • dJ710H13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
transcription factor binding site profile
0.95
kinase
0.89
virus perturbation
0.88
biological term
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2483.64   (req: < 5)
Gene RIFs: 415   (req: <= 3)
Antibodies: 764   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2483.64   (req: >= 5)
Gene RIFs: 415   (req: > 3)
Antibodies: 764   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
73.4
psoriasis vulgaris
1
1
0
1.2
54.4
1
1
0
2.1
12.8
monocyte percentage of leukocytes
1
1
1
7.7
BMI-adjusted hip circumference
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
73.4
psoriasis vulgaris
0
1.2
54.4
0
2.1
12.8
monocyte percentage of leukocytes
1
7.7
BMI-adjusted hip circumference
1
1.1
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98330
20613
Rat
RGD:620758
116490
Dog
snail family transcriptional repressor 1
VGNC:46584
485924
Horse
snail family transcriptional repressor 1
VGNC:23370
100071451
Cow
snail family transcriptional repressor 1
VGNC:35047
504492
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
snail family transcriptional repressor 1
Horse
snail family transcriptional repressor 1
Cow
snail family transcriptional repressor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95863-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (138)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Regulation of PTEN gene transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PTEN Regulation
Regulation of PTEN gene transcription
Signal Transduction
Gene Ontology Terms (34)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (363)
1 – 10 of 363
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
p_int:  0.999998835
p_wrong:  0.000001165
Score:  0.646
Data Source:  BioPlex,STRINGDB
GSE1
Tdark
Novelty:  0.04331197
p_int:  0.999986893
p_ni:  0.000013107
Score:  0.816
Data Source:  BioPlex,STRINGDB
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999951651
p_ni:  0.000048346
p_wrong:  4e-9
Score:  0.749
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.999918561
p_ni:  0.000081439
Score:  0.305
Data Source:  BioPlex,STRINGDB
RCOR3
Tdark
Family:  TF
Novelty:  0.18886215
p_int:  0.996467714
p_ni:  0.003532286
Score:  0.781
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.989618665
p_ni:  0.010381329
p_wrong:  6e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
p_int:  0.937050558
p_ni:  0.062949442
Score:  0.997
Data Source:  BioPlex,STRINGDB
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  0.906496819
p_ni:  0.092839021
p_wrong:  0.00066416
Score:  0.88
Data Source:  BioPlex,STRINGDB
FBXL8
Tdark
Novelty:  0.84091737
p_int:  0.756315906
p_ni:  8.7e-8
p_wrong:  0.243684008
Score:  0.622
Data Source:  BioPlex,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.997
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2483.64

PubMed score by year
PubTator Score  2162.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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