You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC25A27
Mitochondrial uncoupling protein 4

Protein Summary
Description
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371347
  • ENSP00000360398
  • ENSG00000153291
  • ENST00000411689
  • ENSP00000412024

Symbol
  • UCP4
  • UCP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.87
microRNA
0.81
cellular component
0.71
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.24   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.24   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
UCP2
Tbio
Novelty:  0.00083843
Score:  0.913
Data Source:  STRINGDB
SLC25A14
Tbio
Family:  Transporter
Novelty:  0.02268116
Score:  0.913
Data Source:  STRINGDB
UCP1
Tbio
Novelty:  0.00055954
Score:  0.911
Data Source:  STRINGDB
UCP3
Tbio
Novelty:  0.00155156
Score:  0.911
Data Source:  STRINGDB
GALNT14
Tchem
Family:  Enzyme
Novelty:  0.04069117
Score:  0.568
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.555
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.55
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.542
Data Source:  STRINGDB
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
Score:  0.54
Data Source:  STRINGDB
GPX1
Tbio
Family:  Enzyme
Novelty:  0.000826
Score:  0.524
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial Uncoupling Proteins
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Reactome
The fatty acid cycling model
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial Uncoupling Proteins
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
The fatty acid cycling model
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
4
4
3
41.9
98.6
lipoprotein-associated phospholipase A(2) change measurement
1
1
1
83.5
response to darapladib
1
1
1
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
3
41.9
98.6
lipoprotein-associated phospholipase A(2) change measurement
1
83.5
response to darapladib
1
83.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 27
VGNC:7922
472019
Macaque
solute carrier family 25 member 27
704343
Mouse
MGI:1921261
74011
Rat
RGD:620787
85262
Dog
solute carrier family 25 member 27
VGNC:46303
609887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 27
Macaque
solute carrier family 25 member 27
Mouse
Rat
Dog
solute carrier family 25 member 27
Publication Statistics
PubMed Score 52.24
PubMed score by year
PubTator Score 34.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title