Tdark GUCA1C Guanylyl cyclase-activating protein 3

Protein Summary

Description

Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Uniprot Accession IDs

• O95843
• O95844
• Q9UNM0
• GCAP 3

Gene Name

• GUCA1C

Ensembl ID

• ENST00000261047
• ENSP00000261047
• ENSG00000138472

Symbol

• GCAP3
• GCAP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.64
cell type or tissue	0.63
disease	0.62
protein domain	0.58
cell line	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.16   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.16   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0