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Tdark
GUCA1C
Guanylyl cyclase-activating protein 3

Protein Summary
Description
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261047
  • ENSP00000261047
  • ENSG00000138472

Symbol
  • GCAP3
  • GCAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.64
cell type or tissue
0.63
disease
0.62
protein domain
0.58
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (44)
1 – 10 of 44
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.966
Data Source:  STRINGDB
GUCY2F
Tbio
Family:  Kinase
Novelty:  0.03634576
Score:  0.961
Data Source:  STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.945
Data Source:  STRINGDB
CNGA1
Tchem
Family:  IC
Novelty:  0.00848214
Score:  0.923
Data Source:  STRINGDB
GUCA1B
Tbio
Family:  Enzyme
Novelty:  0.02031715
Score:  0.91
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.906
Data Source:  STRINGDB
SLC25A18
Tbio
Family:  Transporter
Novelty:  0.00270676
Score:  0.8
Data Source:  STRINGDB
MRPS23
Tbio
Novelty:  0.3140597
Score:  0.745
Data Source:  STRINGDB
MORC1
Tbio
Novelty:  0.0182807
Score:  0.706
Data Source:  STRINGDB
CIP2A
Tbio
Novelty:  0.00992381
Score:  0.679
Data Source:  STRINGDB
Pathways (10)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
39.6
smoking status measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
39.6
smoking status measurement
1
26.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 1C
VGNC:1833
460572
Macaque
guanylate cyclase activator 1C
706071
Dog
guanylate cyclase activator 1C
VGNC:41563
487968
Horse
guanylate cyclase activator 1C
VGNC:18655
100071815
Opossum
guanylate cyclase activator 1C
100010555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 1C
Macaque
guanylate cyclase activator 1C
Dog
guanylate cyclase activator 1C
Horse
guanylate cyclase activator 1C
Opossum
guanylate cyclase activator 1C
Publication Statistics
PubMed Score 3.79
PubMed score by year
PubTator Score 3.04
PubTator score by year