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Tbio
LATS1
Serine/threonine-protein kinase LATS1

Protein Classes
Protein Summary
Description
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253339
  • ENSP00000253339
  • ENSG00000131023
  • ENST00000392273
  • ENSP00000444678
  • ENST00000543571
  • ENSP00000437550

Symbol
  • WARTS
  • wts
  • WARTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.97
biological process
0.91
kinase
0.8
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.48   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.48   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Protein-Protein Interactions (126)
1 – 10 of 126
MOB1B
Tbio
Family: Enzyme
Novelty: 0.0718959
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDC42BPA
Tchem
Family: Kinase
Novelty: 0.02575412
p_int: 0.989021993
p_ni: 0.010978007
Data Source: BioPlex
TYMS
Tclin
Family: Enzyme
Novelty: 0.00087522
p_int: 0.976934142
p_ni: 0.023065858
Score: 0.222
Data Source: BioPlex,STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.929900363
p_ni: 0.070099637
Data Source: BioPlex
MOB1A
Tbio
Family: Enzyme
Novelty: 0.01430129
Score: 0.999
Data Source: Reactome,STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.999
Data Source: Reactome,STRINGDB
SAV1
Tbio
Novelty: 0.00962335
Score: 0.998
Data Source: STRINGDB
WWTR1
Tbio
Novelty: 0.00431186
Score: 0.991
Data Source: Reactome,STRINGDB
WWC1
Tbio
Novelty: 0.00905646
Score: 0.989
Data Source: Reactome,STRINGDB
NF2
Tbio
Novelty: 0.00055092
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  273.48

PubMed score by year
PubTator Score  107.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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