You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EML2
Echinoderm microtubule-associated protein-like 2

Protein Summary
Description
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245925
  • ENSP00000245925
  • ENSG00000125746
  • ENST00000536630
  • ENSP00000442365
  • ENST00000587152
  • ENSP00000468312

Symbol
  • EMAP2
  • EMAPL2
  • ELP70
  • EMAP2
  • EMAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
transcription factor perturbation
0.74
protein domain
0.73
gene perturbation
0.68
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
6
23
4.2
98.2
9
8
4
1.1
97.2
apolipoprotein B measurement
1
3
3
89.7
blood urea nitrogen measurement
2
2
2
88.7
glucose tolerance test
5
2
5
88.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
23
4.2
98.2
4
1.1
97.2
apolipoprotein B measurement
3
89.7
blood urea nitrogen measurement
2
88.7
glucose tolerance test
5
88.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
echinoderm microtubule associated protein like 2
715009
Mouse
MGI:1919455
72205
Rat
RGD:621066
192360
Dog
echinoderm microtubule associated protein like 2
VGNC:40347
476434
Horse
echinoderm microtubule associated protein like 2
VGNC:17565
100070888
Species
Name
OMA
EggNOG
Inparanoid
Macaque
echinoderm microtubule associated protein like 2
Mouse
Rat
Dog
echinoderm microtubule associated protein like 2
Horse
echinoderm microtubule associated protein like 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95834-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (33)
1 – 10 of 33
TUBB2A
Tclin
Novelty:  0.00902924
p_int:  0.999999696
p_ni:  3.04e-7
p_wrong:  1e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
p_int:  0.99999965
p_ni:  3.49e-7
p_wrong:  1e-9
Score:  0.697
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.999995361
p_ni:  0.000004639
Score:  0.552
Data Source:  BioPlex,STRINGDB
SYAP1
Tbio
Novelty:  0.14401351
Score:  0.708
Data Source:  STRINGDB
NCK2
Tbio
Novelty:  0.02220251
Score:  0.673
Data Source:  STRINGDB
UBE3C
Tbio
Family:  Enzyme
Novelty:  0.05011884
Score:  0.583
Data Source:  STRINGDB
PCDH15
Tbio
Novelty:  0.0097699
Score:  0.571
Data Source:  STRINGDB
NT5C1A
Tbio
Family:  Enzyme
Novelty:  0.00634411
Score:  0.532
Data Source:  STRINGDB
CRMP1
Tbio
Family:  Enzyme
Novelty:  0.01998451
Score:  0.521
Data Source:  STRINGDB
PGM2L1
Tbio
Family:  Enzyme
Novelty:  0.2162449
Score:  0.52
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.02

PubMed score by year
PubTator Score  4.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: