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Tchem
MLYCD
Malonyl-CoA decarboxylase, mitochondrial

Protein Summary
Description
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262430
  • ENSP00000262430
  • ENSG00000103150

Symbol
  • MCD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
biological process
0.83
histone modification site profile
0.73
cellular component
0.67
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.74   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.74   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 214
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Protein-Protein Interactions (88)
1 – 10 of 88
PCDHGA5
Tdark
p_int: 0.999999478
p_ni: 5.2e-7
p_wrong: 1e-9
Data Source: BioPlex
SNTG1
Tbio
Novelty: 0.03490951
p_int: 0.999997131
p_ni: 0.000002869
Data Source: BioPlex
RBM5
Tbio
Novelty: 0.02004452
p_int: 0.999995848
p_ni: 0.000004152
Score: 0.524
Data Source: BioPlex,STRINGDB
PCDHA9
Tdark
Novelty: 0.3255814
p_int: 0.999995013
p_ni: 0.000004987
Score: 0.859
Data Source: BioPlex,STRINGDB
IL25
Tbio
Novelty: 0.02734638
p_int: 0.999989639
p_ni: 0.000010361
Data Source: BioPlex
FYCO1
Tbio
Novelty: 0.13204705
p_int: 0.999987173
p_ni: 0.000012825
p_wrong: 2e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
PCDHA10
Tdark
Novelty: 1.33333333
p_int: 0.999931759
p_ni: 0.00006824
p_wrong: 1e-9
Score: 0.811
Data Source: BioPlex,STRINGDB
PCDHA12
Tdark
Novelty: 4
p_int: 0.999353424
p_ni: 0.000646576
Score: 0.313
Data Source: BioPlex,STRINGDB
PCDHA3
Tdark
Novelty: 2.54545455
p_int: 0.999334586
p_ni: 0.000665342
p_wrong: 7.3e-8
Score: 0.554
Data Source: BioPlex,STRINGDB
SNX9
Tbio
Novelty: 0.00934742
p_int: 0.998848831
p_ni: 0.000496127
p_wrong: 0.000655042
Data Source: BioPlex
Publication Statistics
PubMed Score  37.74

PubMed score by year
PubTator Score  72.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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