You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MLYCD
Malonyl-CoA decarboxylase, mitochondrial

Protein Summary
Description
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262430
  • ENSP00000262430
  • ENSG00000103150

Symbol
  • MCD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
biological process
0.83
histone modification site profile
0.73
cellular component
0.67
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.48   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.48   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 214
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (88)
1 – 10 of 88
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.999999478
p_ni:  5.2e-7
p_wrong:  1e-9
Data Source:  BioPlex
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999997131
p_ni:  0.000002869
Data Source:  BioPlex
RBM5
Tbio
Novelty:  0.01706857
p_int:  0.999995848
p_ni:  0.000004152
Score:  0.524
Data Source:  BioPlex,STRINGDB
PCDHA9
Tdark
Novelty:  0.30110565
p_int:  0.999995013
p_ni:  0.000004987
Score:  0.859
Data Source:  BioPlex,STRINGDB
IL25
Tbio
Novelty:  0.01620324
p_int:  0.999989639
p_ni:  0.000010361
Data Source:  BioPlex
FYCO1
Tbio
Novelty:  0.06181219
p_int:  0.999987173
p_ni:  0.000012825
p_wrong:  2e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
PCDHA10
Tdark
Novelty:  0.73702568
p_int:  0.999931759
p_ni:  0.00006824
p_wrong:  1e-9
Score:  0.811
Data Source:  BioPlex,STRINGDB
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.999353424
p_ni:  0.000646576
Score:  0.313
Data Source:  BioPlex,STRINGDB
PCDHA3
Tdark
Novelty:  0.8622898
p_int:  0.999334586
p_ni:  0.000665342
p_wrong:  7.3e-8
Score:  0.554
Data Source:  BioPlex,STRINGDB
SNX9
Tbio
Novelty:  0.01737783
p_int:  0.998848831
p_ni:  0.000496127
p_wrong:  0.000655042
Data Source:  BioPlex
Pathways (14)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
93.5
alkaline phosphatase measurement
2
2
2
10.2
91.4
low density lipoprotein cholesterol measurement
5
3
6
90.8
serum alanine aminotransferase measurement
2
1
1
9.1
79.7
IGF-1 measurement
1
2
2
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
93.5
alkaline phosphatase measurement
2
10.2
91.4
low density lipoprotein cholesterol measurement
6
90.8
serum alanine aminotransferase measurement
1
9.1
79.7
IGF-1 measurement
2
69.6
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
malonyl-CoA decarboxylase
VGNC:13735
468127
Macaque
malonyl-CoA decarboxylase
714605
Mouse
MGI:1928485
56690
Rat
RGD:620234
85239
Dog
malonyl-CoA decarboxylase
489688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
malonyl-CoA decarboxylase
Macaque
malonyl-CoA decarboxylase
Mouse
Rat
Dog
malonyl-CoA decarboxylase
Publication Statistics
PubMed Score 46.48
PubMed score by year
PubTator Score 72.64
PubTator score by year