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Tchem
MAP4K4
Mitogen-activated protein kinase kinase kinase kinase 4

Protein Summary
Description
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347699
  • ENSP00000314363
  • ENSG00000071054
  • ENST00000350878
  • ENSP00000343658
  • ENST00000634702
  • ENSP00000489579

Symbol
  • HGK
  • KIAA0687
  • NIK
  • HGK
  • NIK
  • MEKKK4
  • FLH21957
  • HEL-S-31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
molecular function
0.97
PubMedID
0.92
disease perturbation
0.87
hub protein
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.82   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.82   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bosutinib
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
56.5
gut microbiome measurement
1
1
1
43.1
leukocyte count
1
1
1
31
C-reactive protein measurement
1
1
1
26.3
neutrophil count
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.5
gut microbiome measurement
1
43.1
leukocyte count
1
31
C-reactive protein measurement
1
26.3
neutrophil count
1
0.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 4
VGNC:299
459459
Macaque
mitogen-activated protein kinase kinase kinase kinase 4
716595
Mouse
MGI:1349394
26921
Rat
RGD:1305322
301363
Dog
mitogen-activated protein kinase kinase kinase kinase 4
VGNC:42984
481331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 4
Macaque
mitogen-activated protein kinase kinase kinase kinase 4
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase kinase 4
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95819-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oxidative Stress Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oxidative Stress Induced Senescence
Protein-Protein Interactions (96)
1 – 10 of 96
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999998444
p_ni: 0.000001556
Score: 0.347
Data Source: BioPlex,STRINGDB
RAP2C
Tbio
Family: Enzyme
Novelty: 0.08572837
p_int: 0.999998062
p_ni: 0.000001938
Score: 0.291
Data Source: BioPlex,STRINGDB
NANOS2
Tbio
Novelty: 0.01489157
p_int: 0.989235319
p_ni: 0.010764681
Score: 0.534
Data Source: BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty: 9.51798561
p_int: 0.980685022
p_ni: 0.0193147
p_wrong: 2.78e-7
Data Source: BioPlex
HEPACAM2
Tbio
Novelty: 0.19192547
p_int: 0.945716676
p_ni: 0.054283324
Score: 0.185
Data Source: BioPlex,STRINGDB
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.910758685
p_ni: 0.089241315
Score: 0.582
Data Source: BioPlex,STRINGDB
ATG14
Tbio
Novelty: 0.00914791
p_int: 0.90903605
p_ni: 0.090963946
p_wrong: 4e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
SLC9A8
Tbio
Family: Transporter
Novelty: 0.03305341
p_int: 0.907524652
p_ni: 0.092475348
Data Source: BioPlex
TEX264
Tdark
Novelty: 0.32406417
p_int: 0.893916203
p_ni: 0.106083782
p_wrong: 1.5e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
CNOT11
Tbio
Novelty: 0.01687183
p_int: 0.860255097
p_ni: 0.139744901
p_wrong: 2e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  161.82

PubMed score by year
PubTator Score  75.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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