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Tbio
BAG3
BAG family molecular chaperone regulator 3

Protein Summary
Description
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369085
  • ENSP00000358081
  • ENSG00000151929

Symbol
  • BIS
  • BIS
  • MFM6
  • BAG-3
  • CAIR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
virus perturbation
0.96
gene perturbation
0.9
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.92   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.92   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.4
91.7
electrocardiography
1
1
10
84.6
4
3
1
1.6
84.4
2
1
0
1.4
82
left ventricular ejection fraction measurement
3
2
3
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.4
91.7
electrocardiography
10
84.6
1
1.6
84.4
0
1.4
82
left ventricular ejection fraction measurement
3
81.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 associated athanogene 3
VGNC:3812
450778
Macaque
BCL2 associated athanogene 3
714420
Mouse
MGI:1352493
29810
Rat
RGD:1307794
293524
Dog
BCL2 associated athanogene 3
VGNC:38365
486916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 associated athanogene 3
Macaque
BCL2 associated athanogene 3
Mouse
Rat
Dog
BCL2 associated athanogene 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95817-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Non-traceable Author Statement (NAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (136)
1 – 10 of 136
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.991687081
p_ni:  0.008312919
Score:  0.178
Data Source:  BioPlex,STRINGDB
HSPB8
Tbio
Novelty:  0.00298618
p_int:  0.987744442
p_ni:  0.012255558
Score:  0.925
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.981870271
p_ni:  0.018129729
Data Source:  BioPlex
SLC27A3
Tbio
Family:  Transporter
Novelty:  0.1037612
p_int:  0.978844294
p_ni:  0.021155706
Score:  0.647
Data Source:  BioPlex,STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
p_int:  0.978034201
p_ni:  0.021965799
Score:  0.309
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.960881042
p_ni:  0.039118958
Score:  0.169
Data Source:  BioPlex,STRINGDB
HSPB2
Tbio
Novelty:  0.00103909
p_int:  0.958897901
p_ni:  0.041102099
Score:  0.545
Data Source:  BioPlex,STRINGDB
KLHL34
Tdark
Novelty:  2.18471039
p_int:  0.922000882
p_ni:  0.077999118
Score:  0.168
Data Source:  BioPlex,STRINGDB
METTL21A
Tbio
Family:  Enzyme
Novelty:  0.31897774
p_int:  0.919476875
p_ni:  0.080523125
Score:  0.237
Data Source:  BioPlex,STRINGDB
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
p_int:  0.862575688
p_ni:  0.137424312
Score:  0.151
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  320.92

PubMed score by year
PubTator Score  188.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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