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Tdark
TMEM50A
Transmembrane protein 50A

Protein Summary
Description
This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374358
  • ENSP00000363478
  • ENSG00000183726

Symbol
  • SMP1
  • SMP1
  • IFNRC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.93
histone modification site profile
0.8
transcription factor perturbation
0.8
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood sedimentation
1
1
1
75.2
mean corpuscular volume
1
1
1
54.4
reticulocyte measurement
1
1
1
53.3
reticulocyte count
1
1
1
53.1
mean reticulocyte volume
1
1
1
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood sedimentation
1
75.2
mean corpuscular volume
1
54.4
reticulocyte measurement
1
53.3
reticulocyte count
1
53.1
mean reticulocyte volume
1
42.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 50A
100424313
Mouse
MGI:1919067
71817
Rat
RGD:1305638
298552
Dog
transmembrane protein 50A
VGNC:47585
478181
Cow
transmembrane protein 50A
VGNC:36092
504456
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 50A
Mouse
Rat
Dog
transmembrane protein 50A
Cow
transmembrane protein 50A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95807-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (32)
1 – 10 of 32
RHCE
Tbio
Novelty: 0.00080592
Score: 0.922
Data Source: STRINGDB
LEPROT
Tbio
Novelty: 0.06240483
Score: 0.91
Data Source: STRINGDB
MACO1
Tbio
Novelty: 0.18252972
Score: 0.793
Data Source: STRINGDB
SYF2
Tbio
Novelty: 0.06114903
Score: 0.792
Data Source: STRINGDB
SELENOF
Tbio
Novelty: 0.01883734
Score: 0.719
Data Source: STRINGDB
RSRP1
Tdark
Novelty: 0.74980508
Score: 0.715
Data Source: STRINGDB
METAP1
Tchem
Family: Enzyme
Novelty: 0.01816253
Score: 0.7
Data Source: STRINGDB
LEPROTL1
Tdark
Novelty: 0.01484804
Score: 0.692
Data Source: STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.62
Data Source: STRINGDB
PBLD
Tbio
Novelty: 0.09777309
Score: 0.617
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.02

PubMed score by year
PubTator Score  4.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer